ID A0A1T0CH50_9GAMM Unreviewed; 377 AA.
AC A0A1T0CH50;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Thiamine biosynthesis protein ThiH {ECO:0000313|EMBL:OOS21686.1};
GN ORFNames=B0682_03310 {ECO:0000313|EMBL:OOS21686.1};
OS Moraxella lincolnii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Moraxella.
OX NCBI_TaxID=90241 {ECO:0000313|EMBL:OOS21686.1, ECO:0000313|Proteomes:UP000191094};
RN [1] {ECO:0000313|EMBL:OOS21686.1, ECO:0000313|Proteomes:UP000191094}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 9405 {ECO:0000313|EMBL:OOS21686.1,
RC ECO:0000313|Proteomes:UP000191094};
RA Salva-Serra F., Engstrom-Jakobsson H., Thorell K., Jaen-Luchoro D.,
RA Gonzales-Siles L., Karlsson R., Yazdan S., Boulund F., Johnning A.,
RA Engstrand L., Kristiansson E., Moore E.;
RT "Draft genome sequence of Moraxella lincolnii CCUG 9405T type strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OOS21686.1}.
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DR EMBL; MUYT01000004; OOS21686.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T0CH50; -.
DR STRING; 90241.B0682_03310; -.
DR OrthoDB; 9801120at2; -.
DR Proteomes; UP000191094; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000191094};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 257..365
FT /note="Biotin and thiamin synthesis-associated"
FT /evidence="ECO:0000259|SMART:SM00876"
SQ SEQUENCE 377 AA; 42872 MW; 7E6E261680D9C44B CRC64;
MTFSTHLDTL NWDEICLSIY GKTDHDVKIA LTKDKPDMND LMALLSPAAS QYLEAMAVKA
QRITRQRFGN TVGLFIPMYL SNLCANECTY CGFSLSNPMT RKTLTHNEIV AECQTINRLG
FSQVLLVTGE YPSQVGMPYF KTHIKTVREH VSSLLMEVQP LSTDDYAQLK SWGLDGVMLY
QETYHKPSYA YHHLKGKKRN FNWRLDAPDR IGQAKIDKIG LGVLVGLSDN FRTDCYMMAE
HLRYLQKTHW QSRFSVAVPR LRPCAGGISP HCTMSDKELV QVLCALRLFA PEVDIVLSTR
ESPTFRDHVI PLMVTQMSAY SQTKPGGYSA ADNQTADDTL EQFSIDDDRH PKAVVRKLTE
QGLQPIWKDW DSYLGRE
//
