ID A0A1T1AV87_RHOFE Unreviewed; 747 AA.
AC A0A1T1AV87;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:OOV07991.1};
GN ORFNames=RF819_15820 {ECO:0000313|EMBL:OOV07991.1};
OS Rhodoferax fermentans.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Rhodoferax.
OX NCBI_TaxID=28066 {ECO:0000313|EMBL:OOV07991.1, ECO:0000313|Proteomes:UP000190750};
RN [1] {ECO:0000313|EMBL:OOV07991.1, ECO:0000313|Proteomes:UP000190750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 7819 {ECO:0000313|EMBL:OOV07991.1,
RC ECO:0000313|Proteomes:UP000190750};
RA Kim Y.J., Farh M.E.-A., Yang D.-C.;
RT "Genome sequencing of Rhodoferax fermentans JCM 7819.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OOV07991.1}.
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DR EMBL; MTJN01000002; OOV07991.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T1AV87; -.
DR STRING; 28066.RF819_15820; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000190750; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:OOV07991.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000190750};
KW Transferase {ECO:0000313|EMBL:OOV07991.1}.
FT DOMAIN 418..479
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 676..747
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 747 AA; 81970 MW; A600C512B14CAE44 CRC64;
MKISEIEVTT PERSAQAVLP VVAATAQSLP EHPQALARAR AFAEPLLSCE ELDTGENTLA
HADAVAVILK RIGGSEAMQA ASYLVYACDH LNKPQEVIAK AFGDNFAALA METTKLVRVQ
RQARMAKATR PAVVVDTPAA QQAAAVQTEN VRKMLLAFSR DLRVVMLRLA SRLQTLRFFA
ATKRPIPEGI AAESLQVFAP LANRLGIWEI KWEMEDLAFR FMEPDTYKQV ARLLDEKRVE
REAHVERMRS QLEADLNANG IVAKVSGRPK HIYSIVKKMR GKSLGFEKVY DVRALRILVA
SVPECYGALS WVHHHFTPIT EEFDDYIAKP KVNGYQSLHT VVRDAAGLPT EIQIRTQAMH
DHAENGVAAH WAYKEAGAKG YAGVSATGAY DAKIAVLRQL LAWERDLSGV QTQDLLDDRI
YVLTPDANIV ELPQGATVVD FAYTVHTDLG HRCRGARVDG AMVPLNTALK NGQTVEVTAA
KEGGPSRDWL NTELGYLVSH RARTKVRAWF NALALSETIA KGREAVEKLL QREGKTALKL
DDLAVQLGFA NATALFEDVG KDEFSLRAIE QVLRPPEAPQ FDANAPVLRK PRSGDNPSKG
GLLVVGVDSL MTQMAKCCKP APPDAICGFV TRGKGVSVHR KDCSNLKEMV ARNGERLIEV
EWGVARAMSG SVFPVDVAVQ AHDRQGLLRD ISEVFTKEKM NVIGVQTQSI KGIAWMTFTV
EVSDSGRLHK VLGLVAELPG VNSARRK
//
