ID A0A1T1ICS8_9PSED Unreviewed; 353 AA.
AC A0A1T1ICS8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Lipopolysaccharide heptosyltransferase 1 {ECO:0000256|ARBA:ARBA00044190};
DE EC=2.4.99.23 {ECO:0000256|ARBA:ARBA00044041};
DE AltName: Full=ADP-heptose:lipopolysaccharide heptosyltransferase I {ECO:0000256|ARBA:ARBA00044330};
GN ORFNames=MF4836_05575 {ECO:0000313|EMBL:OOV99705.1};
OS Pseudomonas sp. MF4836.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1960827 {ECO:0000313|EMBL:OOV99705.1, ECO:0000313|Proteomes:UP000190183};
RN [1] {ECO:0000313|Proteomes:UP000190183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MF4836 {ECO:0000313|Proteomes:UP000190183};
RA Fagerlund A.;
RT "Genome sequencing of bacteria from food industry.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-
CC alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-
CC (2->4)]-alpha-Kdo-(2->6)-lipid A + H(+); Xref=Rhea:RHEA:74067,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:61506, ChEBI:CHEBI:176431,
CC ChEBI:CHEBI:193068, ChEBI:CHEBI:456216; EC=2.4.99.23;
CC Evidence={ECO:0000256|ARBA:ARBA00043802};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004713}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004515}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004515}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004515}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family.
CC {ECO:0000256|ARBA:ARBA00043995}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OOV99705.1}.
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DR EMBL; MVOL01000002; OOV99705.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T1ICS8; -.
DR STRING; 1960827.MF4836_05575; -.
DR Proteomes; UP000190183; Unassembled WGS sequence.
DR GO; GO:0008920; F:lipopolysaccharide heptosyltransferase activity; IEA:InterPro.
DR GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:InterPro.
DR CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR011908; LipoPS_heptosylTferase-I.
DR NCBIfam; TIGR02193; heptsyl_trn_I; 1.
DR PANTHER; PTHR30160:SF19; LIPOPOLYSACCHARIDE HEPTOSYLTRANSFERASE 1; 1.
DR PANTHER; PTHR30160; TETRAACYLDISACCHARIDE 4'-KINASE-RELATED; 1.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Lipopolysaccharide biosynthesis {ECO:0000256|ARBA:ARBA00022985};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OOV99705.1}.
SQ SEQUENCE 353 AA; 39597 MW; 7DA5883F0E2C39B2 CRC64;
MRVLLIKTSS LGDVIHALPA LTDAARAIPG ITFDWVVEEG FAEIPTWHPA VGKVIPVAIR
RWRKNIWQTI KSGEWKRFKQ SVRSTKYDLV IDAQGLLKSA WLTRYVRAPV AGLDKESARE
PLAARFYSRR LAVARGQHAV ERVRQLFAVA LGYDLPQGLG DYGLNQEKLV ELPRKNPFVL
FLHGTTWDTK HWPEAYWREL CERMGNLGVE VRLPWGNVAE KERAERIASG LKNVTVLPKL
NLAGVAKVLV QAQACVAVDT GLGHLAAALD VPTISLFGPT NPGLTGAYGK VQVHMGSDFP
CAPCLQKKCT YQPTPQDQRR FDLKREWPLC FTRLNPERVA SRLSRLLLAE ELR
//
