ID A0A1T2LD08_9GAMM Unreviewed; 1180 AA.
AC A0A1T2LD08;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=BOW52_00685 {ECO:0000313|EMBL:OOZ42970.1};
OS Solemya elarraichensis gill symbiont.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; sulfur-oxidizing symbionts.
OX NCBI_TaxID=1918949 {ECO:0000313|EMBL:OOZ42970.1, ECO:0000313|Proteomes:UP000190198};
RN [1] {ECO:0000313|EMBL:OOZ42970.1, ECO:0000313|Proteomes:UP000190198}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sp-SM6 {ECO:0000313|EMBL:OOZ42970.1};
RA Russell S.L., Corbett-Detig R.B., Cavanaugh C.M.;
RT "Mixed transmission modes and dynamic genome evolution in an obligate
RT animal-bacterial symbiosis.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OOZ42970.1}.
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DR EMBL; MPRK01000005; OOZ42970.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T2LD08; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000190198; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR048472; DNA_pol_IIIA_C.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR049821; PolIIIA_DnaE1_PHP.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF20914; DNA_pol_IIIA_C; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..73
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1180 AA; 131977 MW; 0040E026C99A2B66 CRC64;
MEPRFVHLCI HSEYSLVDGL VRIKPLAAKA SQHGMAAVAM TDRSNLFAMV KFYRAALAAG
VKPIIGVDLL IHNEEDASHP DRLLLLVRNQ AGYLNLNRLI SRAYREGQHL GVPMIERDWL
DEAADGLIAI LPCFDSDIGQ LLLAGKEQEA GQSLAEWRSW FPGSLYLGVS RTGRPNEEEA
VHAMVALSSK EQVPLVALND VRFIDKQDYD AHEVRVCIHE GRTLDDSRRP HLYTEQQYLR
SEDEMCELFA DIPEALHNSV EIARRCNLQL TLGKNYLPEF PIPEGVTTGE YFADISRKGL
DERLQTIYAD NPEEIDAQRA PYDERLQIEL DVINQMGFPG YFLIVADFIQ WAKDNAIPVG
PGRGSGAGSL VAYALKITDL DPIEYDLLFE RFLNPERVSM PDFDIDFCMD NRDRVIDYVA
QTYGRDSVSQ IITYGSMAAK AVVRDVGRVL GHPYGFVDRV AKLVPFEVGM TLTKAMDENP
EFRQAYEEDE EVRQLIDMAL KLEGISRNAG KHAGGVVIAP TVLTDFTPLY CEAGGANLVT
QFDKDDVEAV GLVKFDFLGL RTLTIIDWSI GHVNRHRKKE GEAALDIAKI PMDDAEAFKL
LKTGHTTAVF QLESRGMQEL IRKLQPDNFD DITALVALFR PGPLQSGMVD DFINRKHGRA
QVEYAHPTLE PILRSTYGVI LYQEQVMQIA QDLAGYTLGG ADLLRRAMGK KKPEEMAKQR
EIFLQGATEN DVDEEVSTYI FDLMEKFAGY GFNKSHSAAY ALVSYQTLWL KTHYTAEFMA
AVLSSDMDST DKVKIFVEEC KQLELKLLPP DVNSSAYYFT VSSEGEVVYG LGAIKGVGEA
AIEEIVTCRG EKGYRDLFDM CQRIDLTKVN RRVLESLIRS GAMESFGSNR ATLSAQIPMA
LKMAEQQHAM DAAGQDDLFG MGSDDSEQPS MDESILPSHD EWKNEILLQG ELETLGLYLS
GHPMDAYETD LDALGVRRLQ QLEAAAPPKE KGRGERVRLA GLVTAINRRE TQRGTMASVL
LEDGKGRCDI AFFSDALERL GELLVNGNML LIEGTLSYDA YRDAISIRAD NAVLLEEARQ
LSCRQLYLVI EESQWRKVGE TPAPFVESLM QFMQPYCGGN SRVCLDYRSD HYKGSLLLGE
QWSLHPKEAL LQTLRRTLGD ESVHLGYSEM QDSALAETSV
//
