ID   A0A1T3NMK8_9ACTN        Unreviewed;       413 AA.
AC   A0A1T3NMK8;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=MFS transporter {ECO:0000313|EMBL:OPC78133.1};
GN   ORFNames=B4N89_38700 {ECO:0000313|EMBL:OPC78133.1};
OS   Embleya scabrispora.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Embleya.
OX   NCBI_TaxID=159449 {ECO:0000313|EMBL:OPC78133.1, ECO:0000313|Proteomes:UP000190037};
RN   [1] {ECO:0000313|EMBL:OPC78133.1, ECO:0000313|Proteomes:UP000190037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF3 {ECO:0000313|EMBL:OPC78133.1,
RC   ECO:0000313|Proteomes:UP000190037};
RA   Vazquez M., Ceapa C.D., Rodriguez Luna D., Sanchez Esquivel S.;
RT   "Draft genome sequence of Streptomyces scabrisporus NF3, endophyte isolated
RT   from Amphipterygium adstringens.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OPC78133.1}.
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DR   EMBL; MWQN01000003; OPC78133.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T3NMK8; -.
DR   STRING; 159449.B4N89_38700; -.
DR   OrthoDB; 145388at2; -.
DR   Proteomes; UP000190037; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06173; MFS_MefA_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR010290; TM_effector.
DR   PANTHER; PTHR23513; INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR   PANTHER; PTHR23513:SF6; MULTIDRUG EFFLUX PUMP TAP; 1.
DR   Pfam; PF05977; MFS_3; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190037};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        45..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        89..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        164..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        225..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        258..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        286..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        310..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        352..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..400
FT                   /note="Major facilitator superfamily (MFS) profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
SQ   SEQUENCE   413 AA;  42153 MW;  67BC2E5CD23CFFFC CRC64;
     MTSNGGKLPT GFGRLWTAQT VSSLGDGVSH AALPLLALTL TRDPMALAVV TGAGTLPWLL
     FGVLGGALVD RWDRRRTMWV ADTARAALLV IPAAAAVLDV LSIPLLATVA FLLGLGGLFF
     DTAATAYLPD LLRRDCALLE RANSRLRGTQ IAASGFVGPP AGSALLALGR AVPLLADAVS
     FLLSALLVRT LPAMPRPEPE ARESLLRQAR AGASYVFRDR LLLGLALRPA IGNIAFVAVE
     TVLALFAHDR LGMDAYGFGL LLTAEAAGGL LGAGLASYLG RRLGTGTALT CTAAVEGLAV
     LGLAAAPNPY LAGLALAGCG AGVGATMVLG PSLRQAIVPA HLMGRVASTS RMLGMCAAPF
     GAFLGGWLAT TYDVRAPLYA AAGLLLAMTA VTASMTDNRR VEAALRAAAP VGV
//