ID A0A1T3P5E4_9ACTN Unreviewed; 361 AA.
AC A0A1T3P5E4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=B4N89_27100 {ECO:0000313|EMBL:OPC84110.1};
OS Embleya scabrispora.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Embleya.
OX NCBI_TaxID=159449 {ECO:0000313|EMBL:OPC84110.1, ECO:0000313|Proteomes:UP000190037};
RN [1] {ECO:0000313|EMBL:OPC84110.1, ECO:0000313|Proteomes:UP000190037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF3 {ECO:0000313|EMBL:OPC84110.1,
RC ECO:0000313|Proteomes:UP000190037};
RA Vazquez M., Ceapa C.D., Rodriguez Luna D., Sanchez Esquivel S.;
RT "Draft genome sequence of Streptomyces scabrisporus NF3, endophyte isolated
RT from Amphipterygium adstringens.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPC84110.1}.
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DR EMBL; MWQN01000001; OPC84110.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T3P5E4; -.
DR STRING; 159449.B4N89_27100; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000190037; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:OPC84110.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000190037}.
FT DOMAIN 21..340
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 361 AA; 38376 MW; E704DA72D88095D1 CRC64;
MTTPTTEHDQ PVLTHRQGAL GRIVLNRPAA LNALTHDMVR RIDAALTAWE YDDGVRLVVI
SGAGERGLCA GGDIRAIHAD AVSGGTASLD FWRDEYRLNA RIARYPKAYV AVMDGIVMGG
GVGISAHGKV RIVTERSTIA MPETGIGFVP DVGGTHLLAR APGESGTHLA LTGSAISAGD
AIACGLADHF VPSHRLDAVI EALATGTPAD VLGRFADPAP SGELAERRAW IDTCYASDNV
EEILERLEDS GEPAAKQAAE QIRAKSPTAL KVTLASLRRA RELDSLEAVL EQEYRVSSAA
LTAPDLAEGI RAQVIDKDRT PNWSPPTLDA VRPEDVGRFF RAPAEGAPRL DFASVTTEVN
R
//
