ID   A0A1T4JMF5_9FIRM        Unreviewed;       357 AA.
AC   A0A1T4JMF5;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=(R,R)-butanediol dehydrogenase / meso-butanediol dehydrogenase / diacetyl reductase {ECO:0000313|EMBL:SJZ31376.1};
GN   ORFNames=SAMN02745118_00211 {ECO:0000313|EMBL:SJZ31376.1};
OS   Selenihalanaerobacter shriftii.
OC   Bacteria; Bacillota; Clostridia; Halanaerobiales; Halobacteroidaceae;
OC   Selenihalanaerobacter.
OX   NCBI_TaxID=142842 {ECO:0000313|EMBL:SJZ31376.1, ECO:0000313|Proteomes:UP000190625};
RN   [1] {ECO:0000313|Proteomes:UP000190625}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-73 {ECO:0000313|Proteomes:UP000190625};
RA   Varghese N., Submissions S.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; FUWM01000003; SJZ31376.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T4JMF5; -.
DR   STRING; 142842.SAMN02745118_00211; -.
DR   Proteomes; UP000190625; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08233; butanediol_DH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43161:SF23; (R,R)-BUTANEDIOL DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR43161; SORBITOL DEHYDROGENASE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190625};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          12..353
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   357 AA;  38670 MW;  391D94B7D0D136FE CRC64;
     MIDKMNALRW HGRNDIRIDE VAIPKVNSGE VKIKIEWCGI CGSDLYEYKS GPLFIPESKS
     HPLTGRKAPV ILGHEIAGEV VEVAHDVKEI QVGDRVTVEP IRSCGTCVQC NEGYYNLCSN
     RGFHGFDGGG GGLAEYTTCN ADMVHKLPKK MSMEQAALVE PLAAAIHAIR RGRFAQGQTA
     AIFGTGPIGL ALISAVKVAG AKKIIAVEIA EKRRKIAKEF GADIVLNSNE EDVIAEITKL
     TDGQGVDIAF ETTGVEVSYN NAVTATINSG KIVVVSLWGK EIEINLNDLV LTEKEVIGSI
     AYRDVFPVTM TLIAEGSIKP EKMITKQIGL EEAVEEGFNE LVVNKDENIK ILVNPSK
//