ID A0A1T4JUH7_9FIRM Unreviewed; 204 AA.
AC A0A1T4JUH7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Zn-dependent protease (Includes SpoIVFB) {ECO:0000313|EMBL:SJZ33784.1};
GN ORFNames=SAMN02745973_00101 {ECO:0000313|EMBL:SJZ33784.1};
OS Garciella nitratireducens DSM 15102.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae; Garciella.
OX NCBI_TaxID=1121911 {ECO:0000313|EMBL:SJZ33784.1, ECO:0000313|Proteomes:UP000196365};
RN [1] {ECO:0000313|EMBL:SJZ33784.1, ECO:0000313|Proteomes:UP000196365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15102 {ECO:0000313|EMBL:SJZ33784.1,
RC ECO:0000313|Proteomes:UP000196365};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M50B family.
CC {ECO:0000256|ARBA:ARBA00007931}.
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DR EMBL; FUWV01000001; SJZ33784.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4JUH7; -.
DR OrthoDB; 9800627at2; -.
DR Proteomes; UP000196365; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06158; S2P-M50_like_1; 1.
DR InterPro; IPR008915; Peptidase_M50.
DR InterPro; IPR044537; S2P-M50-like.
DR PANTHER; PTHR35864; ZINC METALLOPROTEASE MJ0611-RELATED; 1.
DR PANTHER; PTHR35864:SF1; ZINC METALLOPROTEASE MJ0611-RELATED; 1.
DR Pfam; PF02163; Peptidase_M50; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SJZ33784.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000196365};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..176
FT /note="Peptidase M50"
FT /evidence="ECO:0000259|Pfam:PF02163"
SQ SEQUENCE 204 AA; 23716 MW; E46C3C78E3A0313B CRC64;
MLFFNFIQII YTIPPILIAL TFHEFSHGFI AYKLGDPTAK EKGRLSLNPF RHLDPIGFLM
LLFFKFGWAK PVPYNPYYFS NRKRGTFLVA LAGPLSNLVL AFLSIIILFV LQPVNGIVSN
FFQLLFLYNI IFFIFNLIPI PPLDGFKIII SLLPKTVENL FLKYERFGYL ILLILIITDL
LDKILLPMIH FVMEKLIFLA NIFF
//
