ID A0A1T4KE82_9ACTN Unreviewed; 333 AA.
AC A0A1T4KE82;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=D-lactate dehydrogenase {ECO:0000313|EMBL:SJZ40701.1};
GN ORFNames=SAMN06298223_0228 {ECO:0000313|EMBL:SJZ40701.1};
OS Olsenella sp. KH1P3.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Olsenella.
OX NCBI_TaxID=1945884 {ECO:0000313|EMBL:SJZ40701.1, ECO:0000313|Proteomes:UP000190585};
RN [1] {ECO:0000313|Proteomes:UP000190585}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KH1P3 {ECO:0000313|Proteomes:UP000190585};
RA Varghese N., Submissions S.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; FUWQ01000001; SJZ40701.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4KE82; -.
DR OrthoDB; 117809at2; -.
DR Proteomes; UP000190585; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12183; LDH_like_2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43026; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR PANTHER; PTHR43026:SF1; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000190585}.
FT DOMAIN 4..324
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 111..299
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 333 AA; 36164 MW; 589B5F5A0D5048BB CRC64;
MKVLFYGTKS YDRQSFEKEL VDYPDVQVEF IDSNLTPVTA ALAQGYDAVC AFVNADISPM
TLEILRGLGV GLVLMRCAGF DAVNVDYAKQ VGMKVTRVPA YSPEAIAEHA MALALAANRR
ICKGYNRVRD NNFDLTGLVG STLHGKTAGI IGTGRIGAAL CRICKGFGMK VLGADLYPNQ
SLVDQGIVDE YVDYDTIYAK SDMISLHAFL NEESHHMIND ESIAKMKDGM IFINTGRGGL
VDTQALIRGI ISGKIGAAGL DVYEEENANV YQNREGEVID SVTARLCSFP NVVMTSHQAF
FTHEALGQIA RVTLDNAQAF ATGTDFVERS VVC
//
