ID   A0A1T4KFX8_9FIRM        Unreviewed;       469 AA.
AC   A0A1T4KFX8;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Alanine or glycine:cation symporter, AGCS family {ECO:0000313|EMBL:SJZ41286.1};
GN   ORFNames=SAMN02745973_00504 {ECO:0000313|EMBL:SJZ41286.1};
OS   Garciella nitratireducens DSM 15102.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae; Garciella.
OX   NCBI_TaxID=1121911 {ECO:0000313|EMBL:SJZ41286.1, ECO:0000313|Proteomes:UP000196365};
RN   [1] {ECO:0000313|EMBL:SJZ41286.1, ECO:0000313|Proteomes:UP000196365}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15102 {ECO:0000313|EMBL:SJZ41286.1,
RC   ECO:0000313|Proteomes:UP000196365};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC       ECO:0000256|RuleBase:RU363064}.
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DR   EMBL; FUWV01000002; SJZ41286.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T4KFX8; -.
DR   OrthoDB; 9804874at2; -.
DR   Proteomes; UP000196365; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF14; SODIUM_AMINO ACID (ALANINE) SYMPORTER-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PIRSF; PIRSF006060; AA_transporter; 3.
DR   PRINTS; PR00175; NAALASMPORT.
DR   PROSITE; PS00873; NA_ALANINE_SYMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363064};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196365};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        70..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        100..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        149..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        180..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        239..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        302..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        386..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        416..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   469 AA;  50700 MW;  FDDA7C9619414723 CRC64;
     MLLLESIVST INSILWDYIL IVALVGTGII ISIRLGFPQI RHFTWGAKKV FGGVFKKGEN
     REGSMSSFQA LATAVAAQIG TGNIAGVATA ITLGGPGAVF WMWVSAFFGM STIFVEATLA
     QKYRETTKNG QLVGGPAYYI KNGLGSKSLA SFFAVSIILA LGFIGNMVQS NSIADVVSRA
     FSIPQLGIGV IIAFFAALIF IGGMKRIASF TETIVPIMAM IYIIGSILIL ILFRQNIILT
     LKAIFIGAFS SKSILGGAAG VGMQQAIRYG VARGLFSNEA GMGSTPNSHA VADVEHPAEQ
     GLSAMIAVCI DTMLVCTATT LIILTTGAQN LGAEGAGVTQ EAFNLAFGPI GQKFLAICLT
     FFAFTTIIGW YYFGENNIRF LFKGKKAIRI YQVIVLIFII LGSFQKVDLV WSLADMFNGI
     MVIPNLIGVL FLFKESKAIL KDYDSQILRG EKLHYKYEYE NNELKDYQK
//