ID   A0A1T4LMD5_9GAMM        Unreviewed;      1050 AA.
AC   A0A1T4LMD5;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN   ORFNames=SAMN02745674_00072 {ECO:0000313|EMBL:SJZ55863.1};
OS   Lysobacter spongiicola DSM 21749.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Lysobacter.
OX   NCBI_TaxID=1122188 {ECO:0000313|EMBL:SJZ55863.1, ECO:0000313|Proteomes:UP000190061};
RN   [1] {ECO:0000313|EMBL:SJZ55863.1, ECO:0000313|Proteomes:UP000190061}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21749 {ECO:0000313|EMBL:SJZ55863.1,
RC   ECO:0000313|Proteomes:UP000190061};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC       ECO:0000256|RuleBase:RU364070}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC       ECO:0000256|RuleBase:RU364070}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU364070}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FUXP01000001; SJZ55863.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T4LMD5; -.
DR   STRING; 1122188.SAMN02745674_00072; -.
DR   OrthoDB; 9757904at2; -.
DR   Proteomes; UP000190061; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004764; MdtF-like.
DR   NCBIfam; TIGR00915; 2A0602; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF13; MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW   Cell membrane {ECO:0000256|RuleBase:RU364070};
KW   Membrane {ECO:0000256|RuleBase:RU364070};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190061};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU364070};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU364070}; Transport {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        366..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        437..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        470..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        540..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        873..890
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        972..992
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
FT   TRANSMEM        1004..1026
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364070"
SQ   SEQUENCE   1050 AA;  112295 MW;  7BFE750CEC6F86AF CRC64;
     MARFFIDRPI FAWVIAIIIM LAGALAIFAL PVSMYPSVAP PSVEVRASYP GASAQVVENS
     VTQVIEQNMT GLDGLMYFSS NSSSNGMATI SLTFESGTDP DIAQVQVQNK LQLAMPLLPQ
     EVQRQGVNVS KSASGFLQVI GFVSEDGSMD RVDISDYVGA NVVDPLSRVP GVGNIQVFGA
     QYAMRIWLDP NKLDTYRLAV PEVIAAIQAQ NAQVAVGQLG GTPSVEGQQL NATINAQDRL
     QTPEQFRDIV VRGETDGSVL RLGDIARVEL GAETYDFITR YNGKPASGIA ISLATGANAL
     ETAAGVEAAL DELAPYFPTG LKAVVPFDTT PFVQVSIKGV IKTLIEAIVL VFLVMYLFLQ
     NFRATLIPTI AVPVVLLGTF GVLAALGFSI NMLTMFAMVL AIGLLVDDAI VVVENVERIM
     SEEGLSPLEA TRKSMDQITG ALVGIGLVLS AVFVPMAFMS GSTGVIYRQF SATIVSAMAL
     SVLVAIVLTP ALCATMLKPL KKGEHHGTRG FFGWFNRKFD QGSSSYRRGV RGVLARRGRF
     LAIFAAMAVV MGLLFVRLPS SFLPPEDQGV LMALVQAPVG STQARTMESI EQLENHFLQN
     EAEVVESVFS VQGFSFAGMG QNAGMAFIKL NDWDERPDAD QSIQAVAGRA MGALGQIKDA
     MVFAFAPPAM PELGIAAGYS FYLQDNAGQG HEALLAARNQ LLGAAAQNEL LVNVRPNGQE
     DTPQLRIDID NQKASALGLS TDAINSTLSL AWGGRYIDDF VDRGRVKRVY VQADAPFRMT
     PEDFSLWSVK NSAGEMVPFP AFASFHWDYG SPRLERYNGV PAMEIQGEAA PGVASGDAMD
     EIERLASELP AGFSVEWTAL SYQERAAGSQ TPLLYTLSLL IVFLCLAALY ESWSVPTAVL
     LVAPLGILGA VLANTMRGME RDVYFQVAML TTVGLTSKNA ILIVEFAKEN LERGMELVEA
     TMTAVRDRLR PILMTSLAFG LGVLPLAIAS GAGSGAQRAI GTGVLGGMIV GTALGLFFIP
     LFFVVIQRVF VKRGKDQTPP AAPAGADSHE
//