ID A0A1T4M2I5_9FIRM Unreviewed; 958 AA.
AC A0A1T4M2I5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:SJZ61173.1};
GN ORFNames=SAMN02745110_01071 {ECO:0000313|EMBL:SJZ61173.1};
OS Eubacterium ruminantium.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=42322 {ECO:0000313|EMBL:SJZ61173.1, ECO:0000313|Proteomes:UP000189857};
RN [1] {ECO:0000313|EMBL:SJZ61173.1, ECO:0000313|Proteomes:UP000189857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17233 {ECO:0000313|EMBL:SJZ61173.1,
RC ECO:0000313|Proteomes:UP000189857};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; FUXA01000006; SJZ61173.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4M2I5; -.
DR OrthoDB; 9757901at2; -.
DR Proteomes; UP000189857; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189857};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..335
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 614..930
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 958 AA; 109329 MW; A61AD258AF1B8873 CRC64;
MNPLKMIKEF LENLKNILLD YLKSRIFPVT VLMIILFFLL GRRLFILQIK NGDNYQVDFT
VRTEKKLKVD SVRGNIYDVN GKLLAYNKLT YDLTFGNNNY LTNRAEDLGI SENQLKNKIV
YNTMQVLAQN NDKITAEFPI EFKNGNYKYT VSGITLKNFL RDAYSKNSID ELTDEELATK
AEDIVYHMRF GGSDVPNFDI STDYTNEDAM VILACRYALW LNRYQQYVPV TIASDISEKS
RSMILEHKDD LTGMDIIVRS ERVYNDAKYF AQIIGYVGKA SEEDLEYFNK NSKVPYTSDD
VVGKIGIERH CEEYLRGTDG EQIMYVDNLG KVIDVVKETP ATAGSDVYLS IDSDLQKYCY
DMLEKEITSI LLSHITPNAY APENNKDNEI PITDVYFALF NNNYIDIEEM SKKSSTEFEQ
GIYNNLESRK KEIILYIRSL LKENPVNNND LSKEYQEYLE FIFKMLGDKG VYLSSEVDRD
SKEFNSYING NKPISDYLRF CLENYYIDTS LIIEEDKYYD SEEIYNELVN YIIKELNGNK
EFKNMIVHSM IQQGYISGSD VIDLIYIQKV LNEENDEDYA AFKNGAFGPY EFMTRKIKNL
EITPAMLALD PCSGAVIITD IYTGELRAFV SYPSYDNNYL TNSVDGDYYN KLLTDKTTPL
YSRASMMRTA PGSTFKIIST VAGVEEGVLG IDEYITDMGV FDKVYTKPAC WVYRDFNTTH
GTIDISKAID ISCNYFYYEV GYRLANDDGY YNDNLGLTRL NKYAAKFGFD GYSGIEIDET
EPHMSDRDAV VSAIGQGTNS YTPVQMSKYI TTIANGGTCY DLTLLDKVAD YEGNIKKTSQ
PKVHSTVDID NALWDKIHNG MRMVVTDDLD HNELLNNLKV KVAGKTGTAQ EDTSRPPHAL
FISYAPYEKP EVSVTCVIQN GYASANAAEL ASFIYAYMYD KEALKDASFG QSKTDTSD
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