ID A0A1T4MKX8_9GAMM Unreviewed; 478 AA.
AC A0A1T4MKX8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=BTE48_00625 {ECO:0000313|EMBL:OPX56976.1};
OS Oceanospirillum multiglobuliferum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Oceanospirillum.
OX NCBI_TaxID=64969 {ECO:0000313|EMBL:OPX56976.1, ECO:0000313|Proteomes:UP000191418};
RN [1] {ECO:0000313|EMBL:OPX56976.1, ECO:0000313|Proteomes:UP000191418}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33336 {ECO:0000313|EMBL:OPX56976.1,
RC ECO:0000313|Proteomes:UP000191418};
RA Carney J.G., Trachtenberg A.M., Rheaume B.A., Linnane J.D., Pitts N.L.,
RA Mykles D.L., Maclea K.S.;
RT "Genome Sequencing of a Marine Spirillum, Oceanospirillum multiglobuliferum
RT ATCC 33336, from Japan.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00004823}.
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPX56976.1}.
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DR EMBL; MTSM01000001; OPX56976.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4MKX8; -.
DR STRING; 64969.SAMN02745127_00831; -.
DR OrthoDB; 9806359at2; -.
DR UniPathway; UPA00126; UER00930.
DR Proteomes; UP000191418; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:OPX56976.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:OPX56976.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000191418};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OPX56976.1}.
FT DOMAIN 5..288
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 322..472
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 478 AA; 52979 MW; 3300E6DAC87D53B0 CRC64;
MTLIPVIMSG GTGSRLWPVS RENHPKPFIT LPDGDNLLRK TLRRASALNH VTEILTVTQQ
SLLFKTEDEY QKEAPLSVPC HYVLEPVRRN TAAAVTAAAL SVAARHGNEA QILVLPADHL
IEDQEAFTQA VQEAQIMVAQ GFHVTFGITP TSAETSFGYI QANQLSPVSK GFKTTGFIEK
PELRVAQDLI QSGDCYWNSG IFCFNVGVLL QDLALHAPEV LRTVEQAINN NTSITLSNQV
TRLDAKSLAL TPDISIDYAL MEKSDLVAVL PCDFSWNDIG SWRAMSELVP EDQFGNRLIG
EVITHQSSKN YVQSKSRLTT LVGVEDLIVI DTSDALMIAH KNHSQGVKEI VTALKKSAHP
THLQHQTGSR PWGTFCVLEE GNNFKIKRIV VKPGGSLSLQ MHYHRSEHWV VVSGIAKVVN
DDQELLLDTN ESTFIRAGHK HRLENPGLID LVLIEVQSGH YLGEDDIVRF DDLYGRHH
//
