ID   A0A1T4N1X1_9FIRM        Unreviewed;       293 AA.
AC   A0A1T4N1X1;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:SJZ73370.1};
GN   ORFNames=SAMN02745973_01528 {ECO:0000313|EMBL:SJZ73370.1};
OS   Garciella nitratireducens DSM 15102.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae; Garciella.
OX   NCBI_TaxID=1121911 {ECO:0000313|EMBL:SJZ73370.1, ECO:0000313|Proteomes:UP000196365};
RN   [1] {ECO:0000313|EMBL:SJZ73370.1, ECO:0000313|Proteomes:UP000196365}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15102 {ECO:0000313|EMBL:SJZ73370.1,
RC   ECO:0000313|Proteomes:UP000196365};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
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DR   EMBL; FUWV01000009; SJZ73370.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T4N1X1; -.
DR   OrthoDB; 9802008at2; -.
DR   Proteomes; UP000196365; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196365};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          11..293
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
FT   COILED          243..270
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   293 AA;  33490 MW;  044F0CE13AF1E3ED CRC64;
     MDLSDFAFSK LNITIVGLGL IGGSFALALK ELNPNKLWAI DKNRDILVMA EEKGVIDKGY
     FDPKTPLEKS DIVVIALYPK SIIKFVKDNL NYFKSGAVIT DTAGLKENIV QEIHTFIRED
     VDFIGGHPMA GREFSGFPYA SKKIFIDSNY ILTPIEENQK EHIHLLKSMI RKIGFKNVVY
     LEPKKHDEII AFISHLPHVI ASTLVNSKML EEGNSCIGRS FKDMTRVAYI NSDLWTELFL
     ENRENLICQI DLFQRDIEKI KKALQKKDRD TLKSILDNSS LKKEEFNNAE TYR
//