ID   A0A1T4P152_9FIRM        Unreviewed;       599 AA.
AC   A0A1T4P152;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Xaa-Pro aminopeptidase {ECO:0000313|EMBL:SJZ85340.1};
GN   ORFNames=SAMN02745973_01890 {ECO:0000313|EMBL:SJZ85340.1};
OS   Garciella nitratireducens DSM 15102.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae; Garciella.
OX   NCBI_TaxID=1121911 {ECO:0000313|EMBL:SJZ85340.1, ECO:0000313|Proteomes:UP000196365};
RN   [1] {ECO:0000313|EMBL:SJZ85340.1, ECO:0000313|Proteomes:UP000196365}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15102 {ECO:0000313|EMBL:SJZ85340.1,
RC   ECO:0000313|Proteomes:UP000196365};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
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DR   EMBL; FUWV01000014; SJZ85340.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T4P152; -.
DR   OrthoDB; 9806388at2; -.
DR   Proteomes; UP000196365; Unassembled WGS sequence.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 2.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000313|EMBL:SJZ85340.1};
KW   Hydrolase {ECO:0000313|EMBL:SJZ85340.1};
KW   Protease {ECO:0000313|EMBL:SJZ85340.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196365}.
FT   DOMAIN          9..134
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          312..530
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          539..599
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   599 AA;  69201 MW;  83EFEF1F7C198EE2 CRC64;
     MGENKKDIIS KLRMIMEKEG LDAYIIPSSD NHQSEYVGEF FKAIAYVSGF TGEAGTIVIT
     KDEAGLWTDG RFFLQAEYQL KGSGIKLFKM GIPNVPTILE YLETKIPNNG KIGFDGRLIS
     MKEGEELVCR LANKNIMVEH HYDLVSAVWK NRPKLSNKPV FILEEKYCGE SRTSKLHRVR
     DVMKQVGANY HIIMTLDDIA WLLNIRGSDI MYSPLVLCYA VISMERVYLF IEESRLDIKV
     KEDLTKDGIV LMPYNDIYNY VKGFENQDKI LIDPDRINYA LYKDIPTYTE KIQKENPTVL
     FKSIKNSVEL ANLEKAHIKD GVAITKFMYW LKTNIGKIKI TEMSASEKLE EFRKMQDNYL
     WQSFEPICAF KEHAAMMHYT STPETDVELK EGYFFLTDTG GNYLEGSTDI TRTIAIGEVS
     KELKYHFTTV LRGMINLARA KFLYGCKGYN LDVLAREPIW NLDMDYKCGT GHGVGYLLNI
     HEGPSGFRWY VVPSKHETHT LEENMVLTDE PGIYIDGSHG IRLENELVVK KGVKNDFGQF
     MHFNVLTYAP IDLDGIALEY LNYDEKLYLN NYHKLVYQKL SSYLTDEERD WLKRYTREI
//