ID A0A1T4PVK6_9FIRM Unreviewed; 752 AA.
AC A0A1T4PVK6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=SAMN02745110_02159 {ECO:0000313|EMBL:SJZ95562.1};
OS Eubacterium ruminantium.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=42322 {ECO:0000313|EMBL:SJZ95562.1, ECO:0000313|Proteomes:UP000189857};
RN [1] {ECO:0000313|EMBL:SJZ95562.1, ECO:0000313|Proteomes:UP000189857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17233 {ECO:0000313|EMBL:SJZ95562.1,
RC ECO:0000313|Proteomes:UP000189857};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FUXA01000014; SJZ95562.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4PVK6; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000189857; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 3.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000189857};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 8..485
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
SQ SEQUENCE 752 AA; 83764 MW; 31B2828D560DFA2F CRC64;
MAEKISAVDY ESEMGQSYVD YAMSVITERA LPDVRDGLKP VQRRILYSLS ELTSSDTPHR
KCARIVGDTM GKYHPHGDSS IYEGLVNLAQ NWKLPIPLVD PHGNFGDVSG SGAAAMRYTE
ARISKYAEEA CMKDLKFCKE DFIPNFDGTE NEPTYLPFQV PNLLVSGSMG IAVGMATNIP
THNLGEVIDG TIAYLENPDI TTEELVDIIK GPDFATGGII NTSRENLISI YETGLGKIRV
RGKVEIRDIG HGRKSICVTE LPFTMIGGTE KFLNTVADLV RNRELPQVVD IADRGDKDGE
CLAIDVKKGT TDEEIENIIN ILYKKAGLED TYGVNINCIN NRKPEVMGLR KILKLYTEFK
NSIYTRKYEK LLDEQEDIKE IKEGLLEAVD VIDLIIEILR GSKDVKTAKR CLMTGETEGI
KFRYKGSEQD AKSLNFSEKQ ADAILAMRLS KLIGLEIEAL RKELSDAEKL IKRYSKLLGS
KAEMRRQMIS DMEELKKYAK PRMTKISDLG EVKVKKAEEK PVEISVLLDR FYYLKCIDKS
VYDKNVAQIE KDYRFSVNTM TDDRLIAFTD KGFAYIIKIS DLVKKQAKKQ TGKGNSIFGK
LSDKGIQIFE FCEMEADENV IFIDALSSII TSNLLFVTDN GRAKRTEGAQ FDVTRKKVAA
VKTGDVPVMV KPADEEGFVV ARSEKGYFVR VKVGDISIQG KGAGGIKLIK LAPDDKLIEA
EVGLTTDAMI GEVSFSRVKL CGTGNKGTKL RV
//
