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Database: UniProt
Entry: A0A1T4Q0X3_9GAMM
LinkDB: A0A1T4Q0X3_9GAMM
Original site: A0A1T4Q0X3_9GAMM 
ID   A0A1T4Q0X3_9GAMM        Unreviewed;       430 AA.
AC   A0A1T4Q0X3;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   05-JUN-2019, entry version 11.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=BTE48_08730 {ECO:0000313|EMBL:OPX55463.1};
OS   Oceanospirillum multiglobuliferum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Oceanospirillaceae; Oceanospirillum.
OX   NCBI_TaxID=64969 {ECO:0000313|EMBL:OPX55463.1, ECO:0000313|Proteomes:UP000191418};
RN   [1] {ECO:0000313|EMBL:OPX55463.1, ECO:0000313|Proteomes:UP000191418}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33336 {ECO:0000313|EMBL:OPX55463.1,
RC   ECO:0000313|Proteomes:UP000191418};
RA   Carney J.G., Trachtenberg A.M., Rheaume B.A., Linnane J.D.,
RA   Pitts N.L., Mykles D.L., Maclea K.S.;
RT   "Genome Sequencing of a Marine Spirillum, Oceanospirillum
RT   multiglobuliferum ATCC 33336, from Japan.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OPX55463.1}.
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DR   EMBL; MTSM01000009; OPX55463.1; -; Genomic_DNA.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000191418; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000191418};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:OPX55463.1};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191418}.
FT   REGION      212    231       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1T4Q0X3}.
SQ   SEQUENCE   430 AA;  45534 MW;  7CEB77F920F5B32D CRC64;
     MKVLVIGNGG REHALAWKAA QSAKVSQVFV APGNAGTALE PKLENVAIDV LDFDALVLFA
     KTNQVELTIV GPEVPLVAGV VDRFRSEGLN IFGPSQGAAQ LEGSKAFTKD FLARHNIPTA
     EYQNFTEIEP ALAYLREKGA PIVIKADGLA AGKGVIVAMT LEEAEDAVKD MLAGNSFGDA
     GSRVVIEEFL DGEEASFIVM VDGKNVLPMA TSQDHKRVGD KDTGPNTGGM GAYSPAPVVT
     QAIHDRVMAE VIMPTVEGMA AEGNVYTGFL YAGLMIMADG TPKVIEYNCR FGDPETQPIM
     LRLQSDLVEL CEAALAGNLD KTEAQWDARP SIGVVIAAGG YPADYAKGDE ITGLPETELE
     GGKVFHAGTT LKDGKVVTNG GRVLCATAMG HSVSEAQANA YQLVKQINWN GAFYRTDIGY
     RAIAREQAKG
//
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