ID A0A1T4Q6L8_9GAMM Unreviewed; 421 AA.
AC A0A1T4Q6L8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=HemY protein {ECO:0000313|EMBL:SJZ99171.1};
GN ORFNames=SAMN02745674_01508 {ECO:0000313|EMBL:SJZ99171.1};
OS Lysobacter spongiicola DSM 21749.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Lysobacter.
OX NCBI_TaxID=1122188 {ECO:0000313|EMBL:SJZ99171.1, ECO:0000313|Proteomes:UP000190061};
RN [1] {ECO:0000313|EMBL:SJZ99171.1, ECO:0000313|Proteomes:UP000190061}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21749 {ECO:0000313|EMBL:SJZ99171.1,
RC ECO:0000313|Proteomes:UP000190061};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC {ECO:0000256|ARBA:ARBA00002962}.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004744}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}.
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DR EMBL; FUXP01000004; SJZ99171.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4Q6L8; -.
DR STRING; 1122188.SAMN02745674_01508; -.
DR OrthoDB; 7053339at2; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000190061; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00540; TPR_hemY_coli; 1.
DR Pfam; PF07219; HemY_N; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000190061};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..133
FT /note="HemY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07219"
FT REGION 388..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 45855 MW; 8A3CD32CA57FE361 CRC64;
MNLFRNLLFW IVLALVGALV AQLLVQDPGY VLVRYRGMDY TTTLAAAVLI GLGALLALWL
VWKMFTLPFQ TLRRRRERAA RARFVDGLDA LELGHWTRAE KLLGETARAP DPESDGVAKL
ASLGAARAAA SRGDAAQAHQ YLDTLGGTHP ASRAVVSAEL ALAAGKPAEA LALLDAPNVQ
PLPPRGLALR AHALAALDRA GDAYALLGPM RQQQALPPAR LDALERDWAQ AGLREAADAN
VLADRWESLP APLRTDPVAV AAYAERAAAL RWEEAAARSV ETALDERWDE SLATLYGRLQ
IGRIDARLER AEGWLDAHPA SPGLLLTLAR LHRAKGQWPQ AEAYLHRALA QGANAEAWEE
LGHGFAQGGD EPRARLCYGN ALRASRGEPV TELPGRDMRS RIYDEAVTEE RDEHGMPRLR
E
//
