ID A0A1T4R5E1_9FIRM Unreviewed; 1274 AA.
AC A0A1T4R5E1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit {ECO:0000313|EMBL:SKA11139.1};
GN ORFNames=SAMN02745885_01929 {ECO:0000313|EMBL:SKA11139.1};
OS Carboxydocella sporoproducens DSM 16521.
OC Bacteria; Bacillota; Clostridia; Eubacteriales;
OC Clostridiales Family XVI. Incertae Sedis; Carboxydocella.
OX NCBI_TaxID=1121270 {ECO:0000313|EMBL:SKA11139.1, ECO:0000313|Proteomes:UP000189933};
RN [1] {ECO:0000313|Proteomes:UP000189933}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16521 {ECO:0000313|Proteomes:UP000189933};
RA Varghese N., Submissions S.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC family. {ECO:0000256|ARBA:ARBA00008483}.
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DR EMBL; FUXM01000025; SKA11139.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4R5E1; -.
DR OrthoDB; 9807568at2; -.
DR Proteomes; UP000189933; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42682; HYDROGENASE-4 COMPONENT F; 1.
DR Pfam; PF00361; Proton_antipo_M; 3.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:SKA11139.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000189933};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..869
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 889..908
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 970..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1004..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1061..1080
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1100..1122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1149..1172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1192..1217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..155
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 282..318
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 334..634
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 812..1114
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
SQ SEQUENCE 1274 AA; 137426 MW; 329F166005BD5B54 CRC64;
MNFGSLFSES SVLALFGAIV ILAGELIALK QMKNLIRLLT ISSIAEIGYV LLGLGLGTYE
GTSGALLHLE YQIVMRALVF VAAAALIARE RSDSIEKLKG IGKAMPVTAT LFGFGLFSVM
GLSPFKGSIS KFLIIYAAIA SGHWFYAAIA TLGSILEAIY FLLIFQKLCF EQPAQSGAST
EKVREASPVL LAAMLVLSGL TALMGLLPEP FIHSVEYMTA VLLGKSAQLP AFESPWSILV
LVPYVGGFIV YLVGRFSAVL RNILAVALTG TTVYLTWQGG DFDSLSRFFA LIMAFIGFLV
TLYSIGYFKD KPHTNRYFFF LFLMIGTLLG LTTSKHLGNF YVYWELMTWT SYFLVIQEQT
EKALRAGFKY FIMCTSGAYI MHFAILTLHV KLGTFDMAAI SANLPELTPS LMLAVLGMFI
IGFGVKTGLV PLHSWLPDAH PVAPSSISAP MSGILTKTGI YGLVRILFVV FGAGLLTELG
TTGQFSTIGF IISMLGALTL LYGEIMALRQ TDIKKMLAYS TMAQVGEIAV TLGIGTYLSL
VGALYHVLNH AIMKNLLFLA VGALIYRLKS QEISKFKGIG RVMPVTSLCF SIGILAIMGL
PPFNGFISKF LMLYASVQSG HLAVAGLILL GSIIGAFYYL KLVRVIFFEK YEGPAVKEAP
ITMLIPVGIL TGLTVFNGLY PQAGLALVKP VVDMIAAKGH MATTAIPDVT IAWPLMAVIP
MVGALVTYLL GRRSARVSGW LAVATMVATL ITVLTVSSGH DIFSRSFALL IAFIGVVNLF
YSLGYMVHGH AQNRFYAFFL LMIGGLLGVA VSKDLFSFFA FWEIMSSWTL YFVIIHEETR
EALQEGFKYF IFNYAGASLM FLGLLVLTAS TGTFEMSELA GRLSALPTGL VAFGLILMLI
GFAMKAAMLP FRIDYQMHPP TAPTPVSGYI SSVLLKSAPF GMVKLFYVFG GISLISKLGL
AGGMPSLMYI VAWVSGLTIL MAAALALLQS GMKRLLIYHT VSQMGYIILG VSLGSSLGMA
GGLLHLVNHM LFKNLLFLVA GAIMVKTGIE NLDKLGGIGR KMPVTLGAFA IGAFSIAGIP
PFNGFTSKWI IYEAAMEKGY VFLAIFSLLA SVLTLASFLK FLHSAFFGQL PKELENVTEA
PWTMQIPMVI LAVLCVVFGV FPGIPLTTIA AIESWLGLTP VSASLFGIDS GLGAWNAGVI
AAVLAIAFIA GVSVYFIGNG KIRYTKIYTC GVTDLTAEEV HVNSHNLYES PKGLVKQCIK
VLYRITGLGK GVEL
//
