ID   A0A1T4RLH2_9ACTN        Unreviewed;       338 AA.
AC   A0A1T4RLH2;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=Pyruvate dehydrogenase E1 component beta subunit {ECO:0000313|EMBL:SKA16783.1};
GN   ORFNames=SAMN02745673_02787 {ECO:0000313|EMBL:SKA16783.1};
OS   Marinactinospora thermotolerans DSM 45154.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Marinactinospora.
OX   NCBI_TaxID=1122192 {ECO:0000313|EMBL:SKA16783.1, ECO:0000313|Proteomes:UP000190637};
RN   [1] {ECO:0000313|EMBL:SKA16783.1, ECO:0000313|Proteomes:UP000190637}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45154 {ECO:0000313|EMBL:SKA16783.1,
RC   ECO:0000313|Proteomes:UP000190637};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; FUWS01000007; SKA16783.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T4RLH2; -.
DR   STRING; 1122192.SAMN02745673_02787; -.
DR   Proteomes; UP000190637; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Pyruvate {ECO:0000313|EMBL:SKA16783.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190637}.
FT   DOMAIN          18..193
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   338 AA;  36576 MW;  60E8AEC96B2028AD CRC64;
     MTELSIAEEP VPAPARGPSM QQAINLALEK VLEEDPTTLV FGEDVGRLGG VFRVTDGLQR
     RFGAERVFDT PLAESGIVGL AVGLAMNGWR PIPELQFDGF AYPALDQIVN QMARMHYRSR
     GTAPMPITLR LPSFGGIQAP EHHGESLEAL FAHVPGLKVC APSDPADAYR LLLQSVRADD
     PVIYMEPKAR YWDRGPAELA EPTEPIGSSR VVRPGRHATL VAWGAMVHRC LQVADLAAED
     GVDLEVVDLR WLKPIDADGL AASVARTRRA VVVHEAPLTA GLGAEVAALI TERTFGDLLA
     PVQRVTGFDV PYPAGPLEPQ YLPTLDRVLL AVQRTLEA
//