ID A0A1T4RUY7_9ACTN Unreviewed; 552 AA.
AC A0A1T4RUY7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN02745673_03013 {ECO:0000313|EMBL:SKA19790.1};
OS Marinactinospora thermotolerans DSM 45154.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Marinactinospora.
OX NCBI_TaxID=1122192 {ECO:0000313|EMBL:SKA19790.1, ECO:0000313|Proteomes:UP000190637};
RN [1] {ECO:0000313|EMBL:SKA19790.1, ECO:0000313|Proteomes:UP000190637}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45154 {ECO:0000313|EMBL:SKA19790.1,
RC ECO:0000313|Proteomes:UP000190637};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FUWS01000007; SKA19790.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4RUY7; -.
DR STRING; 1122192.SAMN02745673_03013; -.
DR OrthoDB; 9808408at2; -.
DR Proteomes; UP000190637; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR007891; CHASE3.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43304:SF1; PAC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43304; PHYTOCHROME-LIKE PROTEIN CPH1; 1.
DR Pfam; PF05227; CHASE3; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000190637};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 222..274
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 310..523
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 273..303
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 552 AA; 61255 MW; EC1C8068BE438986 CRC64;
MSGLAVTGAA KTPETDGRPW TLRRRVTVLL SSVAVVLIAS MATITISVVQ ARDALMRQIE
QLTPAQSAVQ QAMAAYLNQD NGVRGYALTR DEEFLTPYQQ GRTALEESLP TLRKVAGDNE
QIDSAIGALL AAGEAWNDDF AVPTLDKVEA GDEVTAEDYR LGRERFGDLR SAATEAEQII
AEELVSAQEG LTDATQQVVA LLMLVGVVVT VLCVFLWVML QHWVLRPLDE LGRHLQQVSD
GYYAHRIILE GPPEIQRVGR DVDAMRERIV SDLDEVGTAR RTLQEQSELL ERQTEELRRS
NLELEQFAYV ASHDLQEPLR KVASFCQLLQ RRYHGQLDER ADSYIDFAVE GAKRMQTLIN
DLLAFSRVGR TKNFAPVDLN EALNDALGSL DSALEEADAV VTGDELPVVQ GDRTLLTQVF
FNLIGNAVKF RGEEPARVRI SVRQEGEEWV FCCADNGIGI EPQYAERIFV IFQRLHTRDK
YGGTGIGLAM CKKIVEFHGG RIWLDAESDE PGTRICWSLP ADVEREDEAT EDVVTISGPM
AQVGGENEGL RE
//
