ID A0A1T4UAP4_9GAMM Unreviewed; 951 AA.
AC A0A1T4UAP4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Formate dehydrogenase major subunit {ECO:0000313|EMBL:SKA49822.1};
GN ORFNames=SAMN02745132_01233 {ECO:0000313|EMBL:SKA49822.1};
OS Enterovibrio nigricans DSM 22720.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Enterovibrio.
OX NCBI_TaxID=1121868 {ECO:0000313|EMBL:SKA49822.1, ECO:0000313|Proteomes:UP000190162};
RN [1] {ECO:0000313|Proteomes:UP000190162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22720 {ECO:0000313|Proteomes:UP000190162};
RA Varghese N., Submissions S.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
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DR EMBL; FUXU01000010; SKA49822.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4UAP4; -.
DR OrthoDB; 9810782at2; -.
DR Proteomes; UP000190162; Unassembled WGS sequence.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd02792; MopB_CT_Formate-Dh-Na-like; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR43598:SF1; FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT; 1.
DR PANTHER; PTHR43598; TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT B; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR PIRSF; PIRSF036643; FDH_alpha; 3.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Molybdenum {ECO:0000256|ARBA:ARBA00022505};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Periplasm {ECO:0000256|ARBA:ARBA00022764};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 61..117
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 951 AA; 106158 MW; 73B554FB721ED8E7 CRC64;
MKLTKRSDSV SKDEKQLGVS RRAFMRNSTL AAAGGVAAAG MFAPGMMKKA SAKDVDSSKP
KEMKRTICTH CSVGCGVYAG VQDGVWTDQE PAFDHPFNAG GHCAKGAALR EHGHGARRLK
YPMKLVDGKW QKISWDQAIT EVGDKVLEIR EKLGPDSIYF LGSAKFNNEQ AYLFRKMASL
WGTNNVDHQA RICHSTTVAG VANTWGYGAM TNSFNDMHNC KSVLFIGSNP AEAHPVAMQH
ILIAKEKNDC KIVVADPRRS RTAAKADHHF YLRPGTDIAV VWGLLWHIFK NNWEDKEFIH
QRVFGMDEIR EEVAKWPPEV VERVSGATPE QMETAAKMLA QNRPGCVVWC MGGTQHTTGN
NNTRAYCILE LALGNLGRAG GGANIFRGHD NVQGATDLGV LSHTLPGYYG LSEGAWKHWS
KVWEVDFDWV KGRYDPSEYE GTYPMHSAGI PVSRWIDGVL EDKDKIAQKN NISAMFYWGH
AVNSQTRGQD MRKAMNELEM MVIVDPYPTV AAVMNQRKNG VYLLPATTQF ETFGSVTASN
RSIQWRDKVI EPLFDSKPDH EIMYLLSKKL GFSDQLFKNI QINGTEPVIE DITREFNRGM
WTIGMTGQSP ERLKLHQQNW HTFNFTSLEA EGGPLNGETY GLPWPCWGTP ELGHPGSHIL
YDTSKEVARG GGNFRARFGV EYEGKNLLAV DSYSKGCELE DGYPEFTDKM LKQLGWWDDL
TAEEKAAAEG KNWKTDLSGG IQRVAIKHGC MPYGNAKARA IVWTFPDRVP LHREPLFTPR
RDLIAEYPTW DDKADIYRLP TLYKSIQDID VASEYPIILT SGRIVEYEGG GEETRSNPWL
ATLQREMFVE INIVDANNIG IKDGQDVWVE GAEKGRVKVK AMITPRVKEG LAFMPFHFGG
VFEGESLLSK YPEGSQPYVV GEAANTATTY GYDPVTVMQE TKVTLCKISA A
//
