ID A0A1T4V5U7_9FIRM Unreviewed; 342 AA.
AC A0A1T4V5U7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Cell shape-determining protein MreB {ECO:0000256|HAMAP-Rule:MF_02207};
GN Name=mreB {ECO:0000256|HAMAP-Rule:MF_02207};
GN ORFNames=SAMN02745111_00236 {ECO:0000313|EMBL:SKA60286.1};
OS Eubacterium uniforme.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=39495 {ECO:0000313|EMBL:SKA60286.1, ECO:0000313|Proteomes:UP000190814};
RN [1] {ECO:0000313|EMBL:SKA60286.1, ECO:0000313|Proteomes:UP000190814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35992 {ECO:0000313|EMBL:SKA60286.1,
RC ECO:0000313|Proteomes:UP000190814};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Forms membrane-associated dynamic filaments that are
CC essential for cell shape determination. Acts by regulating cell wall
CC synthesis and cell elongation, and thus cell shape. A feedback loop
CC between cell geometry and MreB localization may maintain elongated cell
CC shape by targeting cell wall growth to regions of negative cell wall
CC curvature. {ECO:0000256|HAMAP-Rule:MF_02207}.
CC -!- SUBUNIT: Forms polymers. {ECO:0000256|HAMAP-Rule:MF_02207}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02207}.
CC Note=Membrane-associated. {ECO:0000256|HAMAP-Rule:MF_02207}.
CC -!- SIMILARITY: Belongs to the FtsA/MreB family.
CC {ECO:0000256|ARBA:ARBA00023458, ECO:0000256|HAMAP-Rule:MF_02207}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_02207}.
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DR EMBL; FUXZ01000002; SKA60286.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4V5U7; -.
DR STRING; 39495.SAMN02745111_00236; -.
DR OrthoDB; 9768127at2; -.
DR Proteomes; UP000190814; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR CDD; cd10225; MreB_like; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR HAMAP; MF_02207; MreB; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR004753; MreB.
DR PANTHER; PTHR42749; CELL SHAPE-DETERMINING PROTEIN MREB; 1.
DR PANTHER; PTHR42749:SF1; CELL SHAPE-DETERMINING PROTEIN MREB; 1.
DR Pfam; PF06723; MreB_Mbl; 1.
DR PRINTS; PR01652; SHAPEPROTEIN.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_02207};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960, ECO:0000256|HAMAP-
KW Rule:MF_02207}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02207};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_02207};
KW Reference proteome {ECO:0000313|Proteomes:UP000190814}.
FT BINDING 204..207
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02207"
SQ SEQUENCE 342 AA; 37448 MW; C02F06F420901874 CRC64;
MAIGFYGVDI GSNNIKIYNS NTKEISNFKN IVAIKDGAMF DYGNGAYEMY EKTPTNIKCV
FPVTDGVITD MTNMISSFEQ YFIMANKPKM VSGGKFLVAV PTDITEIEKH GFSEVVSDSN
IKVKELYVVE RPIAEAVGLG IDINKPNGNM IINIGGSTTE ISILSQGGLV LSKIIKMGGN
ILDDAIASAV KKKYNLLIGV KTAERIKNQI ADVLVSDEDD ELLEVDVYGR NMITGLPSSR
QIGADVVNKA ITHNLNEIIY NIKTLLDRTP PELIVDIKKN GIYLTGGTSS IRNLDILISN
ETGFKVNTVN EPGESVIRGV TKIISDSSYK NLMYEPKIPQ YL
//
