ID A0A1T4VA75_9FIRM Unreviewed; 610 AA.
AC A0A1T4VA75;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Radical SAM superfamily enzyme YgiQ, UPF0313 family {ECO:0000313|EMBL:SKA61823.1};
GN ORFNames=SAMN02745111_00573 {ECO:0000313|EMBL:SKA61823.1};
OS Eubacterium uniforme.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=39495 {ECO:0000313|EMBL:SKA61823.1, ECO:0000313|Proteomes:UP000190814};
RN [1] {ECO:0000313|EMBL:SKA61823.1, ECO:0000313|Proteomes:UP000190814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35992 {ECO:0000313|EMBL:SKA61823.1,
RC ECO:0000313|Proteomes:UP000190814};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; FUXZ01000003; SKA61823.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4VA75; -.
DR STRING; 39495.SAMN02745111_00573; -.
DR OrthoDB; 9801424at2; -.
DR Proteomes; UP000190814; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR025288; DUF4080.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF18; RADICAL SAM SUPERFAMILY PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF13311; DUF4080; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000190814}.
FT DOMAIN 1..138
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 187..406
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 610 AA; 71685 MW; 3AAEF393E9A8139E CRC64;
MKIVLVALNA KYVHSNLAVY DLEAYFKKHN PQVDCELEVC EYTINHNLDL ILQALYKQKA
DVYAFSCYIW NIKEVLTLTH ELKKLLPESL IWLGGPEASY GADKYLKENK ELEGIMVGEG
EATFAKLMKI WVKLGIDGLA SENRKKDPYE KINGIVYRKD NGGITENKGT ERIDLDDIPF
VYKDLSKFEN RIIYYETSRG CPFSCSYCLS SIDKAVRFRS FEIVRKELDS FLERKVPQVK
FIDRTFNCNK IHAREIWRYI SEHDNGVTNF HFEVAADLIE DEDIDIFKNM REGLIQLEIG
LQSTNIQTIE AIRRKMDIGS VKDTLLKIRN LGNIHQHLDL IAGLPYEGFE SFRKSFNDAM
EMKPNQLQLG FLKVLKGSYM GEMTEEYDIK HSDVQPFEVL STKWIDYDEI MVLKNIEEMV
EVYYNSDQFE YTLPYVTSFF KSQFDFYKEL GDYYEKKNLF GIGFKRENRY ITLIKFMEKK
IDDAEKHNGK SKSFKMITHS INKNVSIEFD YDLFIELLTF DYYLRENAKS RPMWLKSKSI
YSKDKTTHIE SMSDETYNFI MSLGEVYIEI DDETGEKEKS NHHGEYVLAE FNYNKRSRLS
HNAAVKFYKK
//
