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Database: UniProt
Entry: A0A1T4VP07_9FIRM
LinkDB: A0A1T4VP07_9FIRM
Original site: A0A1T4VP07_9FIRM 
ID   A0A1T4VP07_9FIRM        Unreviewed;       401 AA.
AC   A0A1T4VP07;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   13-FEB-2019, entry version 8.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=SAMN02745111_01358 {ECO:0000313|EMBL:SKA66659.1};
OS   Eubacterium uniforme.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=39495 {ECO:0000313|EMBL:SKA66659.1, ECO:0000313|Proteomes:UP000190814};
RN   [1] {ECO:0000313|EMBL:SKA66659.1, ECO:0000313|Proteomes:UP000190814}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35992 {ECO:0000313|EMBL:SKA66659.1,
RC   ECO:0000313|Proteomes:UP000190814};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; FUXZ01000007; SKA66659.1; -; Genomic_DNA.
DR   BioCyc; GCF_900167115:B5D16_RS06755-MONOMER; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000190814; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000190814};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190814};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN        8    124       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      132    310       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND       7     14       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    200    200       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     100    100       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     185    185       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   401 AA;  43846 MW;  665FBA7F0D2DC172 CRC64;
     MINVAVLGYG TVGSGVVEVI NTNNELINKR VGDTVKIKYV LDLRDFPGDV VENILVKDYD
     VIVNDPEVSI IAEAMGGIDF PYECAKKAIA AGKSYCTSNK ELVAKHGPEL IKLAKENNVN
     FLFEASVGGG IPVIRPINES LTPDDIVEVV GILNGTTNYI LSKMAKEGSD FDTVLKRAQD
     LGYAERNPEA DVEGYDACRK IAILSSLATG KYVNFEDIKT EGITKITDVD FKYANLLGLS
     VKLFGRFKKV DGKYFAMVSP VMIDKTHPLY SVEDVKNGIL VRGNMVGDVM FYGSGAGKLP
     TASAVVSDIV EAARAIGRNI NIIMSDEKLE LSDISEFESR FFVRVKNADK DAIESVFGDV
     EIINLGEIDD EVGFITRSMT EKAFAEAESK FDNVITRIRI M
//
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