ID   A0A1T4VZW2_9GAMM        Unreviewed;       422 AA.
AC   A0A1T4VZW2;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:SKA70338.1};
GN   ORFNames=SAMN02745130_00706 {ECO:0000313|EMBL:SKA70338.1};
OS   Thiothrix eikelboomii.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC   Thiotrichaceae; Thiothrix.
OX   NCBI_TaxID=92487 {ECO:0000313|EMBL:SKA70338.1, ECO:0000313|Proteomes:UP000190460};
RN   [1] {ECO:0000313|EMBL:SKA70338.1, ECO:0000313|Proteomes:UP000190460}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49788 {ECO:0000313|EMBL:SKA70338.1,
RC   ECO:0000313|Proteomes:UP000190460};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; FUYB01000002; SKA70338.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T4VZW2; -.
DR   STRING; 92487.SAMN02745130_00706; -.
DR   OrthoDB; 6139495at2; -.
DR   Proteomes; UP000190460; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR18919:SF107; 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00737; THIOLASE_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003557};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190460};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SKA70338.1}.
FT   DOMAIN          25..289
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          298..419
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        108
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        377
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        407
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   422 AA;  44447 MW;  328EA5947B575AB2 CRC64;
     MNTKVNPFAD SEAAALTASY TDIWLVAGQR TPFADYNGVL REVAPTDLGI YAARSLLASS
     GIPATEVNAI IAGNMAQASF DAYFLPRHIG LYSGVNPNVP ALLVQRLCCT GFETILTAAD
     QISLGKAKMV LCVGTESMSR NPIAAYTHRS GFRMGQLEFK DFLWEATKDT APGIGMGDTA
     ENLAKRYQIS REEVDRFAEA SFARAVAAWE AGYFQAEVSA VVNSQWELDG YKPRGLKLAD
     RAQSFERDSH VRATHFETLQ KLKPAFGGVQ TGGNSSAIVD GAAAVLVAHG DWVRAHGLKP
     IARIVNGAAV AVPPEIMGIG PAPAIRAAAK RAGIQVSDID RVEINEAFGA QYLACERELD
     LDPSKANVNG GAIAIGHPLG ASGVRLSLTA ARAAQQAGLK YSVASACAGG GQGVAILLEN
     AE
//