ID   A0A1T4W0I8_9FIRM        Unreviewed;       445 AA.
AC   A0A1T4W0I8;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Aminopeptidase {ECO:0000256|PIRNR:PIRNR005700};
GN   ORFNames=SAMN02745111_02091 {ECO:0000313|EMBL:SKA70717.1};
OS   Eubacterium uniforme.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=39495 {ECO:0000313|EMBL:SKA70717.1, ECO:0000313|Proteomes:UP000190814};
RN   [1] {ECO:0000313|EMBL:SKA70717.1, ECO:0000313|Proteomes:UP000190814}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35992 {ECO:0000313|EMBL:SKA70717.1,
RC   ECO:0000313|Proteomes:UP000190814};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|PIRNR:PIRNR005700}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FUXZ01000014; SKA70717.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T4W0I8; -.
DR   STRING; 39495.SAMN02745111_02091; -.
DR   OrthoDB; 1111399at2; -.
DR   Proteomes; UP000190814; Unassembled WGS sequence.
DR   GO; GO:0070005; F:cysteine-type aminopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00585; Peptidase_C1B; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR004134; Peptidase_C1B.
DR   PANTHER; PTHR10363; BLEOMYCIN HYDROLASE; 1.
DR   PANTHER; PTHR10363:SF2; BLEOMYCIN HYDROLASE; 1.
DR   Pfam; PF03051; Peptidase_C1_2; 1.
DR   PIRSF; PIRSF005700; PepC; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|PIRNR:PIRNR005700,
KW   ECO:0000313|EMBL:SKA70717.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR005700};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PIRNR:PIRNR005700};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190814};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807,
KW   ECO:0000256|PIRNR:PIRNR005700}.
FT   ACT_SITE        70
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005700-1"
FT   ACT_SITE        365
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005700-1"
FT   ACT_SITE        387
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005700-1"
SQ   SEQUENCE   445 AA;  51304 MW;  678D84AB79EBBA69 CRC64;
     MKKGISLKKL ESFEKDFDSN IANKIAMNAV TNNGINQAAL NRDVYNNNQN AFSIEVKAGD
     VCNQKQSGRC WMFAALNTFR LQVMDKLNIE NMELSQNYPL FYDKLEKSNL FLENMIETID
     MPVTSREVAF LLMAPLGDGG QWDMFRSLVA KYGVVPKDVM PETEVSSMTR EMDKYLTTKL
     REFACEFRKM KAEGKTVKDL RDAKEEMLNT IYRMLCISLG KPPVKFTWET KDKDGKFIKV
     KDITPQDFYK EYVGMPLNDL VTVINAPTKD KPFYETYTVK YLGSVADGDY PVKYLNLPID
     ELKKIAIKEL KDNKVIWFGS DVGQFSERKK GFLTMDALCI EELFSTKFGM TKEERLDFGE
     SLMTHAMVIT GVDLDEKGKP IKWKVENSWG KDVGFDGYYV MDDEWFSEYV YQILLDKKYL
     NKKQAEAFKK EPIVLEPWDP MGSLA
//