ID A0A1T4WEP2_9CLOT Unreviewed; 456 AA.
AC A0A1T4WEP2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=SAMN05428976_102174 {ECO:0000313|EMBL:SKA75774.1};
OS Clostridium sp. USBA 49.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1881060 {ECO:0000313|EMBL:SKA75774.1, ECO:0000313|Proteomes:UP000190748};
RN [1] {ECO:0000313|EMBL:SKA75774.1, ECO:0000313|Proteomes:UP000190748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USBA 49 {ECO:0000313|EMBL:SKA75774.1,
RC ECO:0000313|Proteomes:UP000190748};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
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DR EMBL; FUYD01000002; SKA75774.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4WEP2; -.
DR STRING; 1881060.SAMN05428976_102174; -.
DR OrthoDB; 9808591at2; -.
DR Proteomes; UP000190748; Unassembled WGS sequence.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21124; SPASM_CteB-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR024025; SCIFF_rSAM_maturase.
DR InterPro; IPR047602; SPASM_CteB-like.
DR InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR NCBIfam; TIGR03974; rSAM_six_Cys; 1.
DR PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR PANTHER; PTHR43273:SF8; RADICAL SAM PROTEIN-RELATED; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF13186; SPASM; 1.
DR SFLD; SFLDG01386; main_SPASM_domain-containing; 1.
DR SFLD; SFLDG01384; thioether_bond_formation_requi; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000190748};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 90..324
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 456 AA; 52757 MW; 2292475397B7AD98 CRC64;
MTLVHKFIQD NNRYMIDVNS GTVHLIDELV YDILDEDKLK SKNELLNTYK DKYTESEIIE
AYEELEELIK EGLLYTKDLY EDIAINDNSK SFIKALCLNV AHDCNLKCKY CFADEGEYKG
CRKIMTPEVG KKAIDFVIKN SGPRKNIEVD LFGGEPLMAF ETIKEIVQYA REQEKIYNKI
IRFTMTTNAT LLNNEIMEYI DKEMGNIVLS IDGRKNVNDN VRVKKDGTGS YEKILPKIKA
MVEKRDKTKQ YYVRGTFTRA NTDFFEDIKH LADLGFKEIS VEPVVLPENH ELSIRKEDLP
TIFEQYDKLY KELLKRHKEG KSFKFYHFNI DLNGGPCVYK RISGCGAGHE YVAITPDGDI
YPCHQFVGNE DFKMGTIFDG NIDNNISDKF KKAHIYNKPT CKDCWARFYC SGGCQANNFN
FNGDIHIPYE LGCEMQKKRI ECAIALKVQM MENKAD
//
