ID A0A1T4XW78_9BACT Unreviewed; 509 AA.
AC A0A1T4XW78;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN02745166_02073 {ECO:0000313|EMBL:SKA93311.1};
OS Prosthecobacter debontii.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Verrucomicrobiaceae; Prosthecobacter.
OX NCBI_TaxID=48467 {ECO:0000313|EMBL:SKA93311.1, ECO:0000313|Proteomes:UP000190774};
RN [1] {ECO:0000313|EMBL:SKA93311.1, ECO:0000313|Proteomes:UP000190774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700200 {ECO:0000313|EMBL:SKA93311.1,
RC ECO:0000313|Proteomes:UP000190774};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
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DR EMBL; FUYE01000005; SKA93311.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4XW78; -.
DR STRING; 48467.SAMN02745166_02073; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000190774; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 14..224
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 276..502
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 509 AA; 55098 MW; 4A719C4A15121D04 CRC64;
MSKSSAPSSP GICYLVGAGP GDPGLLTLKG KECIEAADVL VYDYLCNPEL LRHAKPGTEK
IYVGKKAKDH TLTQDKINEL IVKLTREGKV VTRLKGGDPV LFGRGAEEAT ELAEAGVAFE
IVPGITSAIA GPAYAGIPVT HRDHCSQLTI FTGHEDPTKE ETSLDYAKLA KADGTKVFLM
GVERMGEITG KFIENGASPD TPMALVRWAT HGRQQTLIAT LGTMAERVKE TGFKAPAVAV
VGDVVTERKN INWFESRPLF GKRIVVTRTR QQVGGLSKQL RQLGADVIEL PTIRIEEPQN
LMAFGELVQD CHNYEWIVFT SPNGVDAFFK MFYKLYKDIR SIGGARIAVI GPGTAEKVKE
QHLAVDMMPE KNFVAEGLVA ALKDYQSLEN VSVLWVRGEE TREVIANELT GLGAIVDEAI
AYRTVPEKDD NLEAIARLVN EGADLITFTS ASTVDCFMDL KVALPEGIQI ASIGPITSDA
VRKHGLKVDL EAETSTIPGL VEAVQKALA
//
