ID A0A1T4YYJ0_9ACTN Unreviewed; 802 AA.
AC A0A1T4YYJ0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN ORFNames=SAMN06295964_1399 {ECO:0000313|EMBL:SKB06638.1};
OS Aeromicrobium choanae.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=1736691 {ECO:0000313|EMBL:SKB06638.1, ECO:0000313|Proteomes:UP000191040};
RN [1] {ECO:0000313|EMBL:SKB06638.1, ECO:0000313|Proteomes:UP000191040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9H-4 {ECO:0000313|EMBL:SKB06638.1,
RC ECO:0000313|Proteomes:UP000191040};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; LT796768; SKB06638.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T4YYJ0; -.
DR STRING; 1736691.SAMN06295964_1399; -.
DR OrthoDB; 9802472at2; -.
DR Proteomes; UP000191040; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd04863; MtLigD_Pol_like; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR InterPro; IPR014146; LigD_ligase_dom.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR033649; MtLigD_Pol-like.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:SKB06638.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 581..682
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 450..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 87488 MW; 55D48FF0C5A28DE0 CRC64;
MAGPPTQTVS VDGRLLRLTN SDKIMYPASG TTKAEVIAYY AQVAPWLLPH LAGRTVTRKR
WVNGTGPDAE VFFEKNLPDS APDWIRRVTI KHRSRTNVYP VFESVADLAW AGQVAALELH
VPQWRVDATG VALNPDRLVI DLDPGPGTGL PECAEVAHAA RALLADVGLE CIPVTSGSKG
IHLYAQLDGT HDSDYVNAFA KQVAQALEAS MPELVVSDMS KAKRRGRVLV DWSQNNGNKT
TISPYSLRGR EEPTVAVPRD WDEVDADLRH LTIDEVPARL AERGDPMAAL AAPVADRLAT
YRSMRDANRT PEPVPDSVVR GRDGDPTFVI QEHHARRLHW DFRLERDGVL VSWALPKGVP
DSTTGNHLAV QTEDHPLEYA TFAGTIPKGE YGAGEVTIWD HGHYDLEKWN DHEVIATLHG
TREGGLGGPK RLALIKTGEN WLIHLMKEQS PHAAAKEPAP AKESTAKRTR KKPASARAGF
VPPMLAVLAG GRDASGDSWA YELKWDGIRC VAVVSGEQVR LYSRNHNDVS ASYPELVEEL
AGLGLDVVLD GEIVALDEKG IPSFGRLQQR MGVTKAGDLD RLRRTVPVQL MLFDVLERDG
ASLRDLTYDE RREALDDLGI GTGLVHVPPA HGGTLDEAVA LSRSHKLEGV VAKRRSSTYD
PGSRSTDWLK IKNQDTQEIV IGGWRPSSGG RGIGSLLVGV PVEGGLKYLG RVGTGYSNAE
RLKLRSLLDP LERATSPFVD DVETAASRDA TWTTPKLVGE VVYGDWSPAG HLRHASWRGL
RPDKDAADVV LETSAEVRLT PP
//
