ID A0A1T5DF71_9BACI Unreviewed; 441 AA.
AC A0A1T5DF71;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=UDP-N-acetyl-D-glucosamine dehydrogenase {ECO:0000313|EMBL:SKB70335.1};
GN ORFNames=SAMN06295926_106117 {ECO:0000313|EMBL:SKB70335.1};
OS Lysinibacillus sp. AC-3.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX NCBI_TaxID=1680467 {ECO:0000313|EMBL:SKB70335.1, ECO:0000313|Proteomes:UP000190941};
RN [1] {ECO:0000313|EMBL:SKB70335.1, ECO:0000313|Proteomes:UP000190941}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AC-3 {ECO:0000313|EMBL:SKB70335.1,
RC ECO:0000313|Proteomes:UP000190941};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR EMBL; FUYW01000006; SKB70335.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T5DF71; -.
DR STRING; 1680467.SAMN06295926_106117; -.
DR Proteomes; UP000190941; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR017476; UDP-Glc/GDP-Man.
DR InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR InterPro; IPR028359; UDP_ManNAc/GlcNAc_DH.
DR NCBIfam; TIGR03026; NDP-sugDHase; 1.
DR PANTHER; PTHR43491; UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE; 1.
DR PANTHER; PTHR43491:SF1; UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE; 1.
DR Pfam; PF00984; UDPG_MGDP_dh; 1.
DR Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR PIRSF; PIRSF500136; UDP_ManNAc_DH; 1.
DR PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52413; UDP-glucose/GDP-mannose dehydrogenase C-terminal domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 337..432
FT /note="UDP-glucose/GDP-mannose dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00984"
SQ SEQUENCE 441 AA; 48414 MW; 22C907AAFEABAEFA CRC64;
MGIKIELRGL ALSKKIKTRS ATIGIVGLGY VGLPLALEIV NKGFAVIGFD KDIEKVTKIK
SGDSYIADMS NAAIEKAVNE QNFEPTYDFS KLAQVDIIII CVPTPTTSDG TPNISYIVDA
ANAIVQNVSS NTLVILESTT YPGTTEEIVQ PILENGNFVI GQDLFLAYSP ERVDPGNFNF
SVSNTPKVVG GITTSCLEVS KLFYESVINT NVFAVTSPKV AEMEKLLENT FRQINIALVN
ELSQICHKMD IDVWEVIEAA STKPYGFMPF TPGPGVGGHC IPVDPKYLLW AGQQHGIAAT
LIETADKINN SMPSFVVARL ETYLNAQGKE ISDAEIVVIG VSYKPNINDF RESPALRVID
ELMDKQCGLN VIDPFIETFT TGNYMLNTVS LTKEIIQKAD AVVILTNHTT IDYSLIDQHA
ALVFDTRNTH HLFENEKYYK L
//
