ID A0A1T5DXD4_9SPHI Unreviewed; 422 AA.
AC A0A1T5DXD4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Dihydrothymine dehydrogenase {ECO:0000256|ARBA:ARBA00032722};
DE AltName: Full=Dihydrouracil dehydrogenase {ECO:0000256|ARBA:ARBA00030119};
GN ORFNames=SAMN05661099_2701 {ECO:0000313|EMBL:SKB76331.1};
OS Daejeonella lutea.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Daejeonella.
OX NCBI_TaxID=572036 {ECO:0000313|EMBL:SKB76331.1, ECO:0000313|Proteomes:UP000189981};
RN [1] {ECO:0000313|Proteomes:UP000189981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22385 {ECO:0000313|Proteomes:UP000189981};
RA Varghese N., Submissions S.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dihydropyrimidine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00010804}.
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DR EMBL; FUYR01000002; SKB76331.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T5DXD4; -.
DR STRING; 572036.SAMN05661099_2701; -.
DR OrthoDB; 9794954at2; -.
DR Proteomes; UP000189981; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR CDD; cd02940; DHPD_FMN; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR005720; Dihydroorotate_DH_cat.
DR PANTHER; PTHR43073; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR PANTHER; PTHR43073:SF2; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF01180; DHO_dh; 1.
DR Pfam; PF14697; Fer4_21; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000189981}.
FT DOMAIN 334..363
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 370..400
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 422 AA; 46085 MW; 2B555ABCB82CF295 CRC64;
MADLSSNFLG IKSPNPFWLA SAPPTDKKIN VLRALEAGWG GIVWKTLGSQ VKNVSSRYSA
VNFHGGKVMG FNNIELISDR PLQINLDEIK EVLRLFPDRA MIVSLMADNS RDSWHELIKK
VEDTGAHGLE LNFGCPHGMT ERGMGAAVGQ DPEIARMVVE WVMECATVPV ITKLTPNVHS
VVPTGKAVVE AGTNALSLIN TIQSVTGINL DTLVPNPNVA GKSVFGGYCG PAVKPIALKF
LTTLGQNELT KNVPVSGIGG VSTWKDAVEF MLLGATNVQV CTAVMTHGFR IIEDLCEGLS
NWMDEKGFAN ATDFIGKSLP VMTNWEELDI NYHIVANINQ DKCIHCGLCY IACEDTAHQA
INLSYGTPYN TYSIKEPECV GCNLCSLVCP VDNCITMIEQ RKGDEYLNWK EFQKRGLPLN
DH
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