ID   A0A1T5F1F9_9FIRM        Unreviewed;      1123 AA.
AC   A0A1T5F1F9;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Diguanylate cyclase (GGDEF) domain-containing protein {ECO:0000313|EMBL:SKB90044.1};
GN   ORFNames=SAMN06296386_108107 {ECO:0000313|EMBL:SKB90044.1};
OS   Lachnospiraceae bacterium.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1898203 {ECO:0000313|EMBL:SKB90044.1, ECO:0000313|Proteomes:UP000191179};
RN   [1] {ECO:0000313|EMBL:SKB90044.1, ECO:0000313|Proteomes:UP000191179}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KH1P17 {ECO:0000313|EMBL:SKB90044.1,
RC   ECO:0000313|Proteomes:UP000191179};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FUZG01000008; SKB90044.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T5F1F9; -.
DR   Proteomes; UP000191179; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 3.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 2.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 2.
DR   Pfam; PF13426; PAS_9; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 2.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 2.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191179}.
FT   DOMAIN          148..282
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          299..332
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          497..551
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          730..859
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          868..1121
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   1123 AA;  131077 MW;  F6AA16AADAA19ACB CRC64;
     MEAVVFEYDI QTDVMNFSRN IVKFIPCQVR IMDFSQSLEL AGKICPDDLK RAIMFFRPIS
     YGTNEIQEYF RCMDFEGKFC WYSVVGRTVL DEKNRPALLY GTYTKIDVDK EEEIREIRAL
     ADEITALDSI DNAGQKIREI YADSTMIHVY NLMMIELSDY DNLKEKIGRG VAEQAMLEIA
     RILRRSLRSY DVIGREAENR LVVCMRNVKD RGIIYDKAAY LIMAVSNLWV NYRMTETSTV
     NIGIAVLPNG MTPEYESMHK KAEVALLHAI KNGKDTFSVY DVEISSQEEL WSRFAEVSNK
     DFVKKTMDSI ESEAFAMDAS GNITYVNPAM REKNYHGIDD IKLKVNGEDD DSWMSLEDPE
     EIRELEANVI FPETGITRSA KVYGIKDQDE KFWVVVIMKI DPDIERIELE KSWSNFHETV
     TQLEDFVWEI NITDNTCVRL QENNVMSIRS RLFVDDYEGL RKYFLDHVVF RRDREEFLYL
     TDPGFLRETV HKGGQQVCKH IRFMHRDGNW HWYSICMAVR KPREDEGEIE KIFLIAMDID
     QMKRSQDRNQ LIELRYRAML DNSTFMSELA RDNERYEHVN ELTGTYVFEY DALKKDYYIC
     TTFEDMFAVT PEMKENEWSM LCGLKPEPEF RDRYLKFIRE VKSGQDTHEV VLRLMNRFNV
     PRWFKITVQT LNGLNNQLTR VTGILQDVNA EMEVKRELEF RADYDELTRL YNSEAFCGKA
     AEILSLYPER DYAVIAADIE HFRIINDRFG IDAGNGCLEY VGKLIQSSLE RDDIACRYEA
     DMFVILFEYE SDDDIMDYVK GLSEQFQYED AKLCGSSLSF GVYKVDDLDI PVRLMCDRAR
     LAKREIKGNK LLNVAVYDDS VRLRQVKIAQ MESEMQRALT EHEFVMFLQP KVDLNTGKIC
     SAEALVRWQH PTRGLVFPNE FLPQFENNGF IKKLDEYMWE RAAEYISELQ KDGIELPISV
     NISRFHVNHT DLLEVLIGLT NKYGIDNHLL QLEITESLFT ADVNELYRTM GELKDLGFVI
     EMDDFGSGYS SLNMLREAPV DVIKIDRYFV DEIMSTKRGR IIIENTITMS KQLGMEVVAE
     GIETKEQADF LKSVNCDVGQ GYFYSKPIPK DEFRKMLDKS FDD
//