ID A0A1T5FWR0_9SPHI Unreviewed; 417 AA.
AC A0A1T5FWR0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=SAMN05660841_03589 {ECO:0000313|EMBL:SKC00596.1};
OS Sphingobacterium nematocida.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Sphingobacterium.
OX NCBI_TaxID=1513896 {ECO:0000313|EMBL:SKC00596.1, ECO:0000313|Proteomes:UP000190150};
RN [1] {ECO:0000313|Proteomes:UP000190150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24091 {ECO:0000313|Proteomes:UP000190150};
RA Varghese N., Submissions S.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
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DR EMBL; FUZF01000019; SKC00596.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T5FWR0; -.
DR STRING; 1513896.SAMN05660841_03589; -.
DR Proteomes; UP000190150; Unassembled WGS sequence.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251}.
FT DOMAIN 74..184
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 417 AA; 48977 MW; C1C9DCCB04DD7CEC CRC64;
MRTALSFIFA TMSTFLVSGQ QIDSTYVGDL LKKHSDLFKQ VLDHPTHNEV QILYTQIDRD
KNNIPHFKSY SYRLDPTWYF YPASTVKLPT AIFALEKINE LKIKGLNKDT PLKIDSTYER
QTSVQTDTSS DNNLPSIAHY IKKVLLTSDN DAHNRLFEFV GRAEINQKLK KHGSKYSRIV
NRLAIGDKGI WAKHTNPFTF YKDGKNIYQQ DAQYDPEDYA MPWLKNTVQG KGYMNANDEL
INEPWSFEGL NVYALEDQQL LLRKLLFPEA FPVKQRFNLT EDDYRFLYHY MSRGPQEVTS
PKYDSKEFWP TYSKFVYFGR DKSVKSFQNV RSFNKYGDSY GYNIDNAYIV DFEKGIEFLV
AVVIQSNEDG IYNDGIYEYE TITYPFLKNL GQVLYQEELK RPRPYRPNLK RFISEQK
//
