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Database: UniProt
Entry: A0A1T5FWS1_9MICC
LinkDB: A0A1T5FWS1_9MICC
Original site: A0A1T5FWS1_9MICC 
ID   A0A1T5FWS1_9MICC        Unreviewed;       327 AA.
AC   A0A1T5FWS1;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   13-FEB-2019, entry version 8.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=SAMN05660473_03567 {ECO:0000313|EMBL:SKC00601.1};
OS   Arthrobacter sp. 49Tsu3.1M3.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=1279029 {ECO:0000313|EMBL:SKC00601.1, ECO:0000313|Proteomes:UP000189904};
RN   [1] {ECO:0000313|EMBL:SKC00601.1, ECO:0000313|Proteomes:UP000189904}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=49Tsu3.1M3 {ECO:0000313|EMBL:SKC00601.1,
RC   ECO:0000313|Proteomes:UP000189904};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; FUZD01000021; SKC00601.1; -; Genomic_DNA.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000189904; Unassembled WGS sequence.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000189904};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN        7    189       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      204    281       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        182    182       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   327 AA;  34296 MW;  FC4D1505B16D7C1B CRC64;
     MPAPTPTYTF LGPEGTFTEA ALMQVPDAAE AIRIPSSNVN TALDKVRDGS ADAAMVPIEN
     SVEGGVTATL DAIATGQDLR ILREALVPIS FVLVARPGVA LGDIRRVSTH GHAWAQCRLW
     VDANIPNAEY IPGSSTAAAA MGLLDGDGAH YDAAICAPIV ATEQPGLKVL AENIGDNPGA
     VTRFVLVGRP GELPAPTGAD KTTVVVPLPE DRPGALMEIL DQFATRGVNL SRIESRPTGQ
     YLGHYFFSID ADGHVADARV ADALAGLHRI SPATRFLGSY RRADGRRTSV APHTSDQAFR
     AAHAWVKDIL DGASALPKYT PGASPRA
//
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