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Database: UniProt
Entry: A0A1T5GAW1_9FIRM
LinkDB: A0A1T5GAW1_9FIRM
Original site: A0A1T5GAW1_9FIRM 
ID   A0A1T5GAW1_9FIRM        Unreviewed;       301 AA.
AC   A0A1T5GAW1;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE            EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN   ORFNames=SAMN06296386_11622 {ECO:0000313|EMBL:SKC05512.1};
OS   Lachnospiraceae bacterium.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1898203 {ECO:0000313|EMBL:SKC05512.1, ECO:0000313|Proteomes:UP000191179};
RN   [1] {ECO:0000313|EMBL:SKC05512.1, ECO:0000313|Proteomes:UP000191179}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KH1P17 {ECO:0000313|EMBL:SKC05512.1,
RC   ECO:0000313|Proteomes:UP000191179};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FUZG01000016; SKC05512.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T5GAW1; -.
DR   OrthoDB; 9774633at2; -.
DR   Proteomes; UP000191179; Unassembled WGS sequence.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR   Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR   InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR   InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR   InterPro; IPR000398; Thymidylate_synthase.
DR   InterPro; IPR020940; Thymidylate_synthase_AS.
DR   NCBIfam; TIGR03284; thym_sym; 1.
DR   PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR   PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR   PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191179};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          8..292
FT                   /note="Thymidylate synthase/dCMP hydroxymethylase"
FT                   /evidence="ECO:0000259|Pfam:PF00303"
FT   ACT_SITE        182
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ   SEQUENCE   301 AA;  34721 MW;  C862161177A37EC6 CRC64;
     MSYADKLFIK NVKDILDHGV SDEGLEVRPK WEDGTPAHTI ALFGVCDRYD LQKEFPIMTV
     RRSFWKSAWD EVSWIWQKKS NNVKDLSSHV WDAWADENGT IGKAYGYQMG CLSKYKDVTE
     EGLKKAFGDT LDQRTIRWEE GACLMDQVDR VIYQLVNDPA SRRIMTNMYN HHDLSEMALS
     PCAYSMTFCV MGNKLSAILN QRSQDMITAN NWNTVQAALL VYAFASAYGY EPGELIHMIG
     NCHIYDRHIE LAHKLIEAEQ FEAPKFTIDT SVHDFYAFTK DSFHLEDYRY SEFKDAIPVA
     I
//
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