ID A0A1T5GAW1_9FIRM Unreviewed; 301 AA.
AC A0A1T5GAW1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=SAMN06296386_11622 {ECO:0000313|EMBL:SKC05512.1};
OS Lachnospiraceae bacterium.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1898203 {ECO:0000313|EMBL:SKC05512.1, ECO:0000313|Proteomes:UP000191179};
RN [1] {ECO:0000313|EMBL:SKC05512.1, ECO:0000313|Proteomes:UP000191179}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KH1P17 {ECO:0000313|EMBL:SKC05512.1,
RC ECO:0000313|Proteomes:UP000191179};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FUZG01000016; SKC05512.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T5GAW1; -.
DR OrthoDB; 9774633at2; -.
DR Proteomes; UP000191179; Unassembled WGS sequence.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000191179};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..292
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 301 AA; 34721 MW; C862161177A37EC6 CRC64;
MSYADKLFIK NVKDILDHGV SDEGLEVRPK WEDGTPAHTI ALFGVCDRYD LQKEFPIMTV
RRSFWKSAWD EVSWIWQKKS NNVKDLSSHV WDAWADENGT IGKAYGYQMG CLSKYKDVTE
EGLKKAFGDT LDQRTIRWEE GACLMDQVDR VIYQLVNDPA SRRIMTNMYN HHDLSEMALS
PCAYSMTFCV MGNKLSAILN QRSQDMITAN NWNTVQAALL VYAFASAYGY EPGELIHMIG
NCHIYDRHIE LAHKLIEAEQ FEAPKFTIDT SVHDFYAFTK DSFHLEDYRY SEFKDAIPVA
I
//