ID A0A1T5HLB0_9BACT Unreviewed; 550 AA.
AC A0A1T5HLB0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Predicted Kef-type K+ transport protein, K+/H+ antiporter domain {ECO:0000313|EMBL:SKC21465.1};
GN ORFNames=SAMN03080601_02419 {ECO:0000313|EMBL:SKC21465.1};
OS Alkalitalea saponilacus.
OC Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Marinilabiliaceae;
OC Alkalitalea.
OX NCBI_TaxID=889453 {ECO:0000313|EMBL:SKC21465.1, ECO:0000313|Proteomes:UP000191055};
RN [1] {ECO:0000313|EMBL:SKC21465.1, ECO:0000313|Proteomes:UP000191055}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24412 {ECO:0000313|EMBL:SKC21465.1,
RC ECO:0000313|Proteomes:UP000191055};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; FUYV01000014; SKC21465.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T5HLB0; -.
DR STRING; 889453.SAMN03080601_02419; -.
DR KEGG; asx:CDL62_00920; -.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000191055; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000191055};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 416..539
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 550 AA; 60652 MW; 1345F05DB72708FD CRC64;
MDWISLISEN PFYEFAIILA LAALLGALGQ LLKQPLIVVF IALGIIVGPS ALDIVSSKEN
INLLAEIGIA VLLFIVGLKL DLRIIKSVGK VALLTGMGQV LFTSLFGYFI GLALGFSSLH
SFYIAVALTF SSTIIIVKLL SDKKEIDSLH GQIAIGFLIV QDIVVILVMI ILSAMGRSEE
ASLTKDVIRT FFSGIGLLVV TVVAMKWIIP WLSAFLAKSQ ELLTLFAIAW AVAFTTAGEL
IGFSGEVGAF LAGVSLASSP FKDVISSRLV SLRDFLLLFF FVLLGLELDM SVISSQISPA
LIFSVFVLVG NPIIVLIIMG IMGYRKRTSF LAGLTVAQIS EFSLIFAGLG LYVGHITEEI
VGLITLVGLI TIGLSTYLIL YSHQIYGFIS PILSIFERSN PFRENEEISS MQKKYDLILI
GLGRFGKKLA ENLDEHPEFN YLVVDFDPEV VKREQKRGRD IIYGDMEDPD LLQQIPHKQA
RIIVSSVADY QHSVQLMKSL RHEKFEGRVY LTAASDESYK LLSVCGAEQI LRPHYMAANN
FYQDYLKKLI
//
