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Database: UniProt
Entry: A0A1T5HT08_9BACT
LinkDB: A0A1T5HT08_9BACT
Original site: A0A1T5HT08_9BACT 
ID   A0A1T5HT08_9BACT        Unreviewed;       515 AA.
AC   A0A1T5HT08;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   16-JAN-2019, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SAMN03080601_03072 {ECO:0000313|EMBL:SKC23787.1};
OS   Alkalitalea saponilacus.
OC   Bacteria; Bacteroidetes; Bacteroidia; Marinilabiliales;
OC   Marinilabiliaceae; Alkalitalea.
OX   NCBI_TaxID=889453 {ECO:0000313|EMBL:SKC23787.1, ECO:0000313|Proteomes:UP000191055};
RN   [1] {ECO:0000313|EMBL:SKC23787.1, ECO:0000313|Proteomes:UP000191055}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 24412 {ECO:0000313|EMBL:SKC23787.1,
RC   ECO:0000313|Proteomes:UP000191055};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; FUYV01000021; SKC23787.1; -; Genomic_DNA.
DR   Proteomes; UP000191055; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000191055};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191055}.
FT   DOMAIN      212    342       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      423    492       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     220    227       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   515 AA;  58602 MW;  33D6C3A248E7EB35 CRC64;
     MAFAKNQGRV DFFIQIFFTN FVLSELKIIN IKLKEGTVKM KLDHQNVWNI CMDLVSKSID
     PLAFQTWFEP IVPLRLEKDV LTIQVPSVYF YEIIEEQYID HVRRALHDVI GNSAKLEYSV
     VMDKGQKRNH NPYTLNLPTA NRADLRNRAV SPGSNNDQPA IKNPFVIPGI KKLNVDPQLN
     ADYTFENFVE GDCNRLARSA SQAVAKNPGK TAFNPLFIYG NSGLGKTHLA QAIGIDVKQS
     MPEKTVLYVS ANKFQTQYTD SIRNNSLNDF LNFYQMIDVL IMDDIQEFAG KTGTQNTFFH
     IFNHLQQSGK QLILTSDQAP ADLQGMEERL LSRFKWGLPA DLQAPDFETR VDILKHKIRK
     DGINVSPEVV HYLASHINHN VRELEGALIS LLFLSTINRD EISLETAKSV VDKLVRKSQR
     ELSVDFIQKT VCKYYGLDPE SLQSKTRKRE IVQARQIAMY FSKNLTNSSL SAIGSKIGKK
     DHATVLHACK TITNLIETDR DFKSQIREIE SQLKC
//
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