ID A0A1T5IUL5_9MICO Unreviewed; 972 AA.
AC A0A1T5IUL5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Multisubunit sodium/proton antiporter, MrpA subunit /multisubunit sodium/proton antiporter, MrpB subunit {ECO:0000313|EMBL:SKC42613.1};
GN ORFNames=SAMN06309945_0850 {ECO:0000313|EMBL:SKC42613.1};
OS Okibacterium fritillariae.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Okibacterium.
OX NCBI_TaxID=123320 {ECO:0000313|EMBL:SKC42613.1, ECO:0000313|Proteomes:UP000190857};
RN [1] {ECO:0000313|EMBL:SKC42613.1, ECO:0000313|Proteomes:UP000190857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2059 {ECO:0000313|EMBL:SKC42613.1,
RC ECO:0000313|Proteomes:UP000190857};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
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DR EMBL; FUZP01000001; SKC42613.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1T5IUL5; -.
DR STRING; 123320.SAMN06309945_0850; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000190857; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000190857};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 74..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 681..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 738..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 843..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 882..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..941
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..108
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 125..398
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 602..665
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 676..755
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 816..937
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
FT REGION 768..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 102966 MW; 51375D3DD2568A17 CRC64;
MTLILALFAA VSVASPLLTR WLSTRVFYVI ALLPAAVFGI TLAQTPTIAS GGVIEEKIEW
IPQLGIALTS RIDALGWLLA LVVTGVGALV LVYCARYFDA DEPGLGRFAG LLLAFAGTMY
GLVTSDDIIV MFMYWEITSI LSYLLIGHYT GRKESRGAAL QALLVTTFGG LVMLVGVVMI
SSFAGTTSIA SIVSEAPQGA GPTVAILLIL VGALSKSAIV PFHFWLPAAM AAPTPVSAYL
HAAAMVKAGI YLVARLAPGY ADIPGWQALL VGLGVWTMIV GAWRSLRQYD LKLVLAYGTV
SQLGFLMVIT GFGSRDAALA AAALLLAHAL YKATLFLVVG IIDHQAGTRD WRKLSGLWRS
TPSLFVITAI AVASMAGIPP LLGFVAKEAV FGAFVEAAIE GDFWGWVALV GTAVGSVLTV
AYSARFLWGA FGNRKKIVPT ELHTDGWGIQ FAPAFLALAT VVLGIAVPLL DPLLALYADT
VPGEGHYHLA LWHGLEPALF ISAAVLVLGG LLFWRRRGVA RLQEKVPPLV DASRGYWAAT
QGVDRLSAKI TIFAQRGGLS QYLSTILVVF VLALGLTATL GRTWPSGIRW FDSPAQLVVA
VVMGIAAIAA ALAKQRMTAV LLAGVTGFGM VGLFALHGAP DLALTQALVE TITVVVFVLV
LRRLPVKIAQ HNKPEQRTRR LIIGVLVGLV MGTIGLIALG ARQAPSIAAE LPRLAYEEGH
GRNIVNVMLV DIRAWDTMGE LSVLVVVATG IASLLFVSGR AKALPRLSGS RNQRRADNRR
NVIDDPQTTE HPESVHRQSW LLGGLKVSSE NRSVLLEVLV RLLFHPAIVV SVFLLFVGHN
SPGGGFAGGL LAGLALVFRY LAGGRYELGE AAPIDPGKVL GVGVLLAVGT AIGSLFFGGE
ILQSAYLEAD VPVLGHLSIG TSSIFDVGVY LVVIGLTLDI LRSLGAEVDR QQEDTDLEAG
TDDDFTPAEV RP
//
