ID   A0A1T5J2B2_9MICO        Unreviewed;      1088 AA.
AC   A0A1T5J2B2;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=SAMN06309945_1139 {ECO:0000313|EMBL:SKC45461.1};
OS   Okibacterium fritillariae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Okibacterium.
OX   NCBI_TaxID=123320 {ECO:0000313|EMBL:SKC45461.1, ECO:0000313|Proteomes:UP000190857};
RN   [1] {ECO:0000313|EMBL:SKC45461.1, ECO:0000313|Proteomes:UP000190857}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM Ac-2059 {ECO:0000313|EMBL:SKC45461.1,
RC   ECO:0000313|Proteomes:UP000190857};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; FUZP01000001; SKC45461.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T5J2B2; -.
DR   STRING; 123320.SAMN06309945_1139; -.
DR   Proteomes; UP000190857; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000190857}.
FT   DOMAIN          32..360
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          361..677
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         53..60
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1088 AA;  121340 MW;  20FF957667B1E23B CRC64;
     MNTLIDNRAG EPAETGPRSY SAVEIAEMLK LPRPTDEQIL VIEAPLQPAM VVAGAGSGKT
     ETMANRIVWL LANRLVEVPQ ILGLTFTRKA AGELQERILT RIEQLGRVIE TGSRDILEAP
     TVSTYNAFAS GIFREYGRSI GREPESTVIT DASAWRLARD IVIRSDDDRL VALDKSIDQI
     TSAVVWLSRS LSDNDAADRG DDILRMVERV VQLEEMPWGS RKRTPSKTVV DTVRDLSALP
     VLLSLADEFA REKRRRGFVE FSDQVALALE ICRRVPRARD DYRSRFRVVI LDEYQDTSVV
     QTDLLSGLFA DHPVMAVGDP NQSIYGWRGA SASNLARFLA DFAPTSPSAT YSLSTSWRNA
     HEILAAANAV AGRLPVLPTV PVSELRASPA AADGRVDLSF TETIDDEARE VAEWFHRELR
     RPTTSGKQRT AAMLCRSVKN IAPFTDALDA ADVPYHVLGL AGLLEQPVIV DLVAALRVLH
     DPTAGSELIR LLTGARWQIG PRDIAALNRL AAWLSDRDTG YALLDDSTRE ALRQSTNPDD
     ARSLVEAIDF LIEAPDTHRA LAGITPEGRR RMRAAATQLA SIRRRGGLDL LDLVSLVVQE
     LLLDIEIAAN ESATLGQASL DAFVEQVESY LAVDESGTLG PFLAWLDEAE KREKLAPRSD
     EPEPGTVQIL TIHGSKGLEW DSVAVPRLVA DEMPGKLRSK RGWTAFGELP FDFRGDRDVL
     PELQWRSAET HLEFDEAYTR FGEELEQRNS EEQRRLAYVA ITRARDALHL GGSFWATQSK
     PREASTYLRE TEEALERLRG TTSDRLPAQS ELDENPLAGI QHRVDWPLDP LGPRRERVTA
     AARAVREADP GRTTRWDADI ALLLAEREDR RTGDQRVALP ARVPASRFKD FVSDPAEVAT
     RLRRPLPEKP YRQTRLGTLF HSWVEQRSGM TGTGDVLDAS LLELDGDDLT ATQYPVEGAE
     LEALRALQAT FEASEWADRK PVDVEIEIDV TLGGQVLICK LDAVYETDGR YQIVDWKTGR
     SPRGDDELEE RQYQLALYRV AYARWKEIPA EDIDAVFYYV AEDTVIRPRT LYSEEELVRR
     WTEAVSRA
//