ID   A0A1T5JF83_9MICO        Unreviewed;       907 AA.
AC   A0A1T5JF83;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=SAMN06309945_1483 {ECO:0000313|EMBL:SKC50014.1};
OS   Okibacterium fritillariae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Okibacterium.
OX   NCBI_TaxID=123320 {ECO:0000313|EMBL:SKC50014.1, ECO:0000313|Proteomes:UP000190857};
RN   [1] {ECO:0000313|EMBL:SKC50014.1, ECO:0000313|Proteomes:UP000190857}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM Ac-2059 {ECO:0000313|EMBL:SKC50014.1,
RC   ECO:0000313|Proteomes:UP000190857};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; FUZP01000001; SKC50014.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T5JF83; -.
DR   STRING; 123320.SAMN06309945_1483; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000190857; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190857};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          20..473
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          843..907
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        851..873
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        881..895
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   907 AA;  96641 MW;  C3C08F0A839A6B5D CRC64;
     MPRSDKNAPA APINERIEDV DVSAEMQGSF LEYAYSVIYS RALPDARDGL KPVQRRILYQ
     MTEMGLRPDR GHVKSARVVG EVMGKLHPHG DSAIYDALVR LAQPFTLRVP LVDGHGNFGS
     LDDGPAASRY TEARLEAAAL ALTADLDEDV VDFVPNYDNQ FQQPEVLPAA YPNLLVNGAS
     GIAVGMATNM APHNLIEVVG AARHLLEHPD ASLDDLMEFV PGPDLPTGGT IVGLDGIRDA
     YATGRGAFKT RARVRIEAIT PRKQGIIVTE LPYLVGPEKV IEKIKDGVNN KKLSGISDVT
     DLTDRTNGLQ LVIGIKTGFS PEAVLEQLYR YTPLEDSFSI NNVALVEGGP RTLGLRELLE
     VYVKHRISVV TRRSTYRLAR RKERLHLVEG LLIAILDIDE VIQVIRASDD SDQARSRLID
     VFDLSQVQAE YILELRLRRL TKFSRIELEA ERDKLLAEIA ELEEILGSTA RLHALVSDEL
     EAVAEQFGTP RRTLLTAAKP SIASAGSRKN QPVLELADTP CRIYLSATGR MVRVDYPGEG
     GLEPVAAPPR RSKHDAVLSM LETSSRTEVG AVTSLGRLIR FSPLELPVVP PNSVQLGAGV
     RIADYITLQP KERVLAVVAL DSAKPIALGT RTGVVKRVTP GDWPNKPEFE IIQLKPKDVV
     VAAAPSTDTD EFVFVTSDAQ LLRFAASAVR PQGRTAGGMA GIKLGAGASV LSFHVVRADE
     TTRTVVATVA ANTSALAGTD PGSGKVSAFD EFPAKGRATG GVRAQRFLKG EDALVVAWVG
     PEPALAVATD GAVRKLPEAL AKRDASGQFL EGVVGYIGAS IATPADAVGA LAAGSDPVPL
     TAAERDTADS APSAPSESPE SAVGTTLTVD GAGSEASVQE ALDTPLASSD IPSVPDNGGE
     SDDAALF
//