ID A0A1U6GLI1_9GAMM Unreviewed; 723 AA.
AC A0A1U6GLI1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=enoyl-CoA hydratase {ECO:0000256|ARBA:ARBA00012076};
DE EC=4.2.1.17 {ECO:0000256|ARBA:ARBA00012076};
GN ORFNames=DABAL43B_1139 {ECO:0000313|EMBL:SLJ84336.1};
OS Psychrobacter sp. DAB_AL43B.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Psychrobacter.
OX NCBI_TaxID=1028416 {ECO:0000313|EMBL:SLJ84336.1, ECO:0000313|Proteomes:UP000190084};
RN [1] {ECO:0000313|EMBL:SLJ84336.1, ECO:0000313|Proteomes:UP000190084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAB_AL43B {ECO:0000313|EMBL:SLJ84336.1};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|RuleBase:RU003707}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR EMBL; LT799838; SLJ84336.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1U6GLI1; -.
DR STRING; 1028416.DABAL43B_1139; -.
DR KEGG; psyc:DABAL43B_1139; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000190084; Chromosome i.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:SLJ84336.1}.
FT DOMAIN 324..502
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 505..605
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 723 AA; 78506 MW; 2337CDFDEE88C5B1 CRC64;
MNTNSVNAIN ALNHFSAESD NGIITVIIDQ ADRKMNVIGD GFTDSFAKMT DSFINDASAK
GLILTSGKET FVVGADIDQL ASIQTAEQAF DLVEDLKASM RKLELSGKPV VAAMTGTALG
GGLELALACH YRIAIDSPKT KLGLPEVKLG LLPGGGGTQR LPRLVGIQAA LELMTQGKEL
RPAAAKDMGL IDAVATDKVD MLKQAKDWII ANPTAQQPWD KKGFQIPGGD SKNPKIVPIF
SIAPAMANQK SHGNYPAITH IMSCVFEGCM VDIDTGLEIE SRYFVGCVLS AESKNMINTL
WIQLNSIKKG QSRPDGFERY KTKKVGILGA GMMGAGIAYV SAKAGIEVVL LDTAIEGAEK
GKNYSTKLLD KAISRGRSTE EKKQALLDKI KTTVSYDDLE GCDLIIEAVF EDVDIKAECT
RKSEAVIPET AVYASNTSTL PITELAKASI RPNQFIGLHF FSPVDKMPLV EIIVGEDTDE
ATLAKSFDYV GQISKTPIVV NDSRGFYTSR VFGTYVSEGI AMLSEGIHPR SIEVAGMKSG
MPMPPLALQD EVSLSLSLHV MQQAKRALEA EGETFTPHPA MPVVEKMVNE FGREGKKVAK
GFYDYPENAE KRLWPELTEL YPTKDEQPSQ QDLVDRLLYV QANETAKCFE ENVVRTVADA
NIGSIFGWGF APNQGGTLQF INSVGVKKFV ERSRELASKY GERFEPAQIL VKMAEKGEEF
VDG
//
