ID   A0A1U7D078_9RHOB        Unreviewed;       425 AA.
AC   A0A1U7D078;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=O-acetylhomoserine sulfhydrylase {ECO:0000313|EMBL:APX21518.1};
DE            EC=2.5.1.49 {ECO:0000313|EMBL:APX21518.1};
GN   ORFNames=Ga0080559_TMP722 {ECO:0000313|EMBL:APX21518.1};
OS   Salipiger profundus.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Salipiger.
OX   NCBI_TaxID=1229727 {ECO:0000313|EMBL:APX21518.1, ECO:0000313|Proteomes:UP000186559};
RN   [1] {ECO:0000313|EMBL:APX21518.1, ECO:0000313|Proteomes:UP000186559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JLT2016 {ECO:0000313|EMBL:APX21518.1,
RC   ECO:0000313|Proteomes:UP000186559};
RA   Tang K.;
RT   "Deep-sea bacteria in the southern Pacific.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; CP014796; APX21518.1; -; Genomic_DNA.
DR   RefSeq; WP_076622146.1; NZ_FOLR01000002.1.
DR   AlphaFoldDB; A0A1U7D078; -.
DR   STRING; 1229727.Ga0080559_TMP722; -.
DR   KEGG; tpro:Ga0080559_TMP722; -.
DR   OrthoDB; 9805807at2; -.
DR   Proteomes; UP000186559; Chromosome.
DR   GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR   PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR   PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186559};
KW   Transferase {ECO:0000313|EMBL:APX21518.1}.
FT   MOD_RES         206
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   425 AA;  45057 MW;  226FAA647CF59878 CRC64;
     MTHGFDTLQV HAGARPDPAT GARQTPVYQT TAYVFRDADH AAALFNLQEV GYIYSRLTNP
     TVAALQERVA TLEGGAGAVC CSSGHAAQIM ALFPLMGPGL NIVASTRAYG GTITQFSQTI
     KRFGWSCTFV DFDDLAAVEA AIDENTRAIF CESIANPGGY VTDLDAIAAI ADKAGLPLIV
     DNTSATPYLC KPIEHGATLV VHSLTKYMTG NGTVTGGAVI DSGKFDWSAS DKFPSLAAPE
     PAYHGLKFHE TFGSLAFTFH SIAIGLRDLG MTLNPQAAHY TLLGIETLSL RMQKHVENAT
     RVASWLENHP AVEQVTYAGL PSSPYNDRVS KICPNGAGGL FTVALKGGYE SCVKFVDSLE
     IFSHVANLGD ARSLVIHSAS TTHRQLTEEQ QIAAGAAPNV VRISIGIEDP EDLIADLDQA
     LAKAG
//