ID A0A1U7D422_9RHOB Unreviewed; 190 AA.
AC A0A1U7D422;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000256|HAMAP-Rule:MF_00768};
GN Name=betI {ECO:0000256|HAMAP-Rule:MF_00768};
GN ORFNames=Ga0080559_TMP2118 {ECO:0000313|EMBL:APX22914.1};
OS Salipiger profundus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Salipiger.
OX NCBI_TaxID=1229727 {ECO:0000313|EMBL:APX22914.1, ECO:0000313|Proteomes:UP000186559};
RN [1] {ECO:0000313|EMBL:APX22914.1, ECO:0000313|Proteomes:UP000186559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLT2016 {ECO:0000313|EMBL:APX22914.1,
RC ECO:0000313|Proteomes:UP000186559};
RA Tang K.;
RT "Deep-sea bacteria in the southern Pacific.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Repressor involved in choline regulation of the bet genes.
CC {ECO:0000256|HAMAP-Rule:MF_00768}.
CC -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC glycine betaine. It represses transcription of the choline transporter
CC BetT and the genes of BetAB involved in the synthesis of glycine
CC betaine. {ECO:0000256|ARBA:ARBA00024936}.
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway [regulation]. {ECO:0000256|ARBA:ARBA00004719,
CC ECO:0000256|HAMAP-Rule:MF_00768}.
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DR EMBL; CP014796; APX22914.1; -; Genomic_DNA.
DR RefSeq; WP_017467663.1; NZ_FOLR01000008.1.
DR AlphaFoldDB; A0A1U7D422; -.
DR STRING; 1229727.Ga0080559_TMP2118; -.
DR KEGG; tpro:Ga0080559_TMP2118; -.
DR OrthoDB; 7618612at2; -.
DR UniPathway; UPA00529; -.
DR Proteomes; UP000186559; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR HAMAP; MF_00768; HTH_type_BetI; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR017757; Tscrpt_rep_BetI.
DR PANTHER; PTHR30055:SF254; HTH-TYPE TRANSCRIPTIONAL REGULATOR BETI; 1.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00768, ECO:0000256|PROSITE-
KW ProRule:PRU00335}; Reference proteome {ECO:0000313|Proteomes:UP000186559};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00768};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00768};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00768}.
FT DOMAIN 5..65
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 28..47
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00768,
FT ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 190 AA; 21285 MW; C1F82F212D77DDAB CRC64;
MNAQTQRRTQ LIEATIHEIG ATGTLAVTVG QIAKRAGVSA ALAFHYFGDK DRLFLAAMRH
ILAVYGDEVR RGLAQSQDPR ERLETLIRAS FSETNFRRDV IATWLNFYVL AHRSTEAQRL
LVIYHRRLHS NLVHELRPLV GAKAPGVARR LAALIDGIYL RFAHFPSDEP EQNASAHVLA
ALENELRALA
//
