ID   A0A1U7DP18_9FLAO        Unreviewed;       586 AA.
AC   A0A1U7DP18;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Phenylalanine 4-monooxygenase {ECO:0000313|EMBL:APY10235.1};
GN   ORFNames=BWZ22_02840 {ECO:0000313|EMBL:APY10235.1};
OS   Seonamhaeicola sp. S2-3.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae.
OX   NCBI_TaxID=1936081 {ECO:0000313|EMBL:APY10235.1, ECO:0000313|Proteomes:UP000187101};
RN   [1] {ECO:0000313|EMBL:APY10235.1, ECO:0000313|Proteomes:UP000187101}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2-3 {ECO:0000313|EMBL:APY10235.1,
RC   ECO:0000313|Proteomes:UP000187101};
RA   Chi W.-J., Kim J.H.;
RT   "Complete genome sequence of Seonamhaeicola sp. S2-3 isolated from seawater
RT   in Jeju island.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954,
CC         ECO:0000256|PIRSR:PIRSR601273-2};
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR   EMBL; CP019389; APY10235.1; -; Genomic_DNA.
DR   RefSeq; WP_076697858.1; NZ_CP019389.1.
DR   AlphaFoldDB; A0A1U7DP18; -.
DR   STRING; 1936081.BWZ22_02840; -.
DR   KEGG; seon:BWZ22_02840; -.
DR   OrthoDB; 9780502at2; -.
DR   Proteomes; UP000187101; Chromosome.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   CDD; cd00361; arom_aa_hydroxylase; 1.
DR   Gene3D; 1.20.58.690; -; 1.
DR   Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR036951; ArAA_hydroxylase_sf.
DR   InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR   PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR   Pfam; PF00351; Biopterin_H; 2.
DR   SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR   PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR601273-2};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:APY10235.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187101}.
FT   DOMAIN          1..342
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   BINDING         131
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         136
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         221
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ   SEQUENCE   586 AA;  65903 MW;  472C53384C9A97AC CRC64;
     MKSLIELNPV LQKLPEHLRQ FIKPQNYEEY SAIDQAVWRY VMRKNVNFLS KVAHKSYLEG
     LQKTGISIDS IPNMYGMNRI LKDIGWAAVA VDGFIPPNAF MEFQAYNVLV IASDIRQLEH
     IEYTPAPDII HEGAGHAPII ANPEYAEYLR RFGEIGCKAI SSAKDYELYE AVRHLSIIKE
     APNTSKNDIA SAEKKVEELQ ENMGMPSEMA LIRNLHWWTV EYGLIGSVEN PKIYGAGLLS
     SIGESEWCMT NAVKKLPYTI EATYQNFDIT KPQPQLFVTP DFAHLSLVLE EFANTMAVRK
     GGLSGVNKLI NSKALGTVEL STGIQISGVF TSVIENEDNP IYIQTTGKTA LAYREKELVG
     HGCETHPKGF GCPIGKLKGI NIAIEDMSPR DLAAYNIYEE QIVTLEFEGG ITVSGEIITG
     KRNLQGKIIL ISFKNCTVSY NNKILFKPSW GIYDMAVGKD IVSAFSGPAD LNSFNLVTHI
     PSEKTIHIKK SEEQLKLETL YQQIRDYRVG KNTIISRTKV LENLIENHPK DWLLPIEIYE
     LAYTSNEENL CKGILNHLEK IKQNRPEVGK LIDDGLKIIQ NKMVYN
//