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Entry: A0A1U7EBT7_9LACT
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ID   A0A1U7EBT7_9LACT        Unreviewed;       413 AA.
AC   A0A1U7EBT7;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=BW721_05115 {ECO:0000313|EMBL:APZ49117.1};
OS   Jeotgalibaca sp. PTS2502.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Carnobacteriaceae;
OC   Jeotgalibaca.
OX   NCBI_TaxID=1903686 {ECO:0000313|EMBL:APZ49117.1, ECO:0000313|Proteomes:UP000187137};
RN   [1] {ECO:0000313|EMBL:APZ49117.1, ECO:0000313|Proteomes:UP000187137}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PTS2502 {ECO:0000313|EMBL:APZ49117.1,
RC   ECO:0000313|Proteomes:UP000187137};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; CP019433; APZ49117.1; -; Genomic_DNA.
DR   RefSeq; WP_076766758.1; NZ_CP019433.1.
DR   KEGG; jep:BW721_05115; -.
DR   KO; K00003; -.
DR   OrthoDB; 1464088at2; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000187137; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000187137};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187137};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN       11    130       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      138    316       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   COILED      381    401       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE    206    206       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     106    106       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     191    191       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   413 AA;  44546 MW;  541CB88C57912396 CRC64;
     MKETVKIGLL GFGTVGYGVY DILKNNQEKY ASLTQINIEV SKILVHDTAA FPEALAAGIP
     LTDQFEEIAQ DDSISIVVEV MGTVDVARNF ITKALNSGKN VVTANKDLLA VHGEELYALA
     EKVGKDLYFE ASVAGGIPIL RALNESYIGD NLQEVLGIVN GTTNFMLTKM QEEHYSYADA
     LALAQQLGFA ESDPTGDVEG LDAARKVVIL TKLAFGKTIT MEQLPTTGIS ALDLADFERA
     KALGYTIKLI GSSKVVDGHL NVEVAPMLVP LDHPLAHVKN ENNAVYVTGE AVGETMMYGP
     GAGRMPTANS VVADILQVAK NIKEDRTGKG LPTITSDVVL GQANPTYTDV LLRFKQVENQ
     GLTITHPQLT QLDGADGKDY IHASQVSKQE LEAIKDQLEK DHQLVFEAVY QSI
//
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