ID A0A1U7EEW9_9LACT Unreviewed; 310 AA.
AC A0A1U7EEW9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Hydroxyacid dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=BW721_05200 {ECO:0000313|EMBL:APZ50256.1};
OS Jeotgalibaca sp. PTS2502.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Jeotgalibaca.
OX NCBI_TaxID=1903686 {ECO:0000313|EMBL:APZ50256.1, ECO:0000313|Proteomes:UP000187137};
RN [1] {ECO:0000313|EMBL:APZ50256.1, ECO:0000313|Proteomes:UP000187137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PTS2502 {ECO:0000313|EMBL:APZ50256.1,
RC ECO:0000313|Proteomes:UP000187137};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP019433; APZ50256.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1U7EEW9; -.
DR STRING; 1903686.BW721_05200; -.
DR KEGG; jep:BW721_05200; -.
DR Proteomes; UP000187137; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43333; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43333:SF1; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000187137}.
FT DOMAIN 19..97
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 98..272
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 310 AA; 34831 MW; 54458546D33DA948 CRC64;
MTDLKNHQIK ELEDSLAGFE LIRTIPEDKR QLSRIEIVVG WTKELTELWQ QGDLISLKWI
QAISAGVNSL PLDSLREHGV MLTNASGIHK DTISEHVIGL ILYHARSFNQ IKLNQQNNHW
DQAVSVQQLE GKTAIIFGIG NIGRRLATLL KAFGVHTIGV NTRGNKVAEV DQTVSQEESN
RYLEQADYVI NILPQTDETK DFFNSDRFKA MKKGTAFFNV GRGNAVDTEA LLTALDSNQL
AFAALDVFET EPLEADSPLW QHDRIFITPH VSGMVEHFRD ALFSVVGPNA QAYGENGKPS
LNMVDYEKRY
//
