ID A0A1U7EUR9_NATPD Unreviewed; 481 AA.
AC A0A1U7EUR9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Xanthine/uracil permease family transport protein {ECO:0000313|EMBL:CAI48717.1};
GN Name=uraA {ECO:0000313|EMBL:CAI48717.1};
GN OrderedLocusNames=NP_1252A {ECO:0000313|EMBL:CAI48717.1};
OS Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS 8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Natronomonas.
OX NCBI_TaxID=348780 {ECO:0000313|EMBL:CAI48717.1, ECO:0000313|Proteomes:UP000002698};
RN [1] {ECO:0000313|EMBL:CAI48717.1, ECO:0000313|Proteomes:UP000002698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 /
RC NCIMB 2260 / Gabara {ECO:0000313|Proteomes:UP000002698};
RX PubMed=16169924; DOI=10.1101/gr.3952905;
RA Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA Oesterhelt D.;
RT "Living with two extremes: conclusions from the genome sequence of
RT Natronomonas pharaonis.";
RL Genome Res. 15:1336-1343(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697}.
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DR EMBL; CR936257; CAI48717.1; -; Genomic_DNA.
DR RefSeq; WP_011322353.1; NC_007426.1.
DR AlphaFoldDB; A0A1U7EUR9; -.
DR STRING; 348780.NP_1252A; -.
DR EnsemblBacteria; CAI48717; CAI48717; NP_1252A.
DR GeneID; 3701095; -.
DR KEGG; nph:NP_1252A; -.
DR eggNOG; arCOG02807; Archaea.
DR HOGENOM; CLU_024508_0_1_2; -.
DR OrthoDB; 27788at2157; -.
DR Proteomes; UP000002698; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR InterPro; IPR045018; Azg-like.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002698};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 481 AA; 50435 MW; F4B50EB65B884E8D CRC64;
MGVGDSLAAY FDFDEYGTDY RTETVAGATT FLAMAYIIVV NPAILSEAIM TDPPAGMNQG
EVIQMLAVVT ILASVAAILV MAFYAKRPFG LAPGMGLNAF FAFTVVIGLG VPWQVALAAV
FVEGLIFIAL TAIGARRYVI ELFPEPVKFA VGAGIGIFLL FLGLQEMNVV AAYPDGTLVE
LGNFLLEPAA LVAVAGLGLT LFLYARGIKG SIIVGILTTA AAGWVAALML PNGEEQFAPP
AYADVQEQGF VPYLLDVQYN FLPLVEGFVS GLGQITEDPL VFLLVVFTFF VVDFFDTAGT
LIGVSGVAGF LDDDGNLPDI DKPLMADAVG TTVGAVIGTS TVTTFIESST GVEEGGRTGF
TALVVGLLFL ASLAVVPLVS LMPLYATYIA LVVVGIIMLQ GVADIDWEDP VWAISGGLTI
TVMPLTASIA DGLAAGILSY PLIKTAVGER RDVTLGQWIL ALALVAYYVF FFLADGGFVA
F
//
