ID A0A1U7EYQ3_NATPD Unreviewed; 1008 AA.
AC A0A1U7EYQ3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=NP_4606A {ECO:0000313|EMBL:CAI50394.1};
OS Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS 8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Natronomonas.
OX NCBI_TaxID=348780 {ECO:0000313|EMBL:CAI50394.1, ECO:0000313|Proteomes:UP000002698};
RN [1] {ECO:0000313|EMBL:CAI50394.1, ECO:0000313|Proteomes:UP000002698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 /
RC NCIMB 2260 / Gabara {ECO:0000313|Proteomes:UP000002698};
RX PubMed=16169924; DOI=10.1101/gr.3952905;
RA Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA Oesterhelt D.;
RT "Living with two extremes: conclusions from the genome sequence of
RT Natronomonas pharaonis.";
RL Genome Res. 15:1336-1343(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR936257; CAI50394.1; -; Genomic_DNA.
DR RefSeq; WP_011324009.1; NC_007426.1.
DR AlphaFoldDB; A0A1U7EYQ3; -.
DR STRING; 348780.NP_4606A; -.
DR EnsemblBacteria; CAI50394; CAI50394; NP_4606A.
DR GeneID; 3702113; -.
DR KEGG; nph:NP_4606A; -.
DR eggNOG; arCOG02333; Archaea.
DR eggNOG; arCOG02340; Archaea.
DR eggNOG; arCOG06408; Archaea.
DR HOGENOM; CLU_000445_114_71_2; -.
DR OMA; MIAERDW; -.
DR OrthoDB; 3369at2157; -.
DR Proteomes; UP000002698; Chromosome.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00130; PAS; 4.
DR Gene3D; 2.10.70.100; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 6.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 4.
DR PANTHER; PTHR43304:SF1; PAC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43304; PHYTOCHROME-LIKE PROTEIN CPH1; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 3.
DR Pfam; PF08448; PAS_4; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00086; PAC; 4.
DR SMART; SM00091; PAS; 5.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 5.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 4.
DR PROSITE; PS50112; PAS; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAI50394.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002698};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAI50394.1}.
FT DOMAIN 159..231
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 234..286
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 283..354
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 354..408
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 485..538
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 555..609
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 611..663
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 664..723
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 801..1008
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 62..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 392..419
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 66..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 113461 MW; 6A2C3CC61FBA7C09 CRC64;
MSEESITDPD SSQGAAAANS THEAFLCATS DAAFLVDAER TDDGYEFTLL EHNDAYRRLT
EHTSSHDTAR NVIPEPATTQ QQSAHHYCRR CVEEQTTLQY AASFATPSAT DRWETTLTPV
VEDGAVDHIV GVVESPTESP REQTQPKDSH ERRHSPEHIH QRLESALDAA DAGVWEVDPE
TRTVYCDDRA CSIFGLSPTS FTGTWTEITE CVHPGDWDDF ETAYDQAVGD PSGREVEFRV
QSNGESANWV RVHAQPVAST DGTPDRLVGT IRDITDEKRR SRKLEQFREA AEQTGHAVCL
LDADGTIEYV NPAFEAITGY DAATAIGEPI QLLRSDAHDR SFYVELWQTI LAGERWEGEA
IKERADGEEI TFSQTVSPLT DDKGDPNGFV LVARDITEKK QREQEINQLR ERLELAIKGA
NISVWDWDIE SNTIELHNSS AIVSRQDSDN SRIKQKEWER RIHPDDIDGI WETFEDHVVE
ESEYYEAEYR VLAGDGDWRW VRDLGQVIER DEDGEPIRAV GVQLDIDDKK RAWITVEQER
DMFTEGPVVL FRWRDEPGWP IEYASDNVEA LLGYEPKELT DDIGSFAEII HDDDIGQARQ
KAEQARKRGR GSHEYRVVTA DGETRWVFEH TKFVQHNTED RRIALGYVVD ITERKRREQE
LETARNELRR IIDLVPDPIH VRDKDGRFIL ANEATAELYG TTPEALNGKD DDDLPFEVQH
SSDCTEDVAA VIDSGERIEA EEELTTAHGD DKTLELTRIP YETTRADTPT ALTYARDVTA
LKAYERTLEQ QRDNLETLNQ VVRHDIRNSL QLVLAYGEML EAHVDGDAAD FVEHVTEAAS
DAVTITETAR DVTEVLLRSA DELTAVNLTC VLDDQVTSIR ASHERATIDI EGSIPDCAVR
ADEMLESAVR NLLSNAIQHN DNDHPRVTVA ATADDETVEL RIADNGPGIP DDQKDRIFQE
GEKGLDSDGT GLGLYLVDTL IDRYDGEIRV EDNDPRGAVF VVELQQAD
//