ID A0A1U7I6H2_9CYAN Unreviewed; 691 AA.
AC A0A1U7I6H2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:OKH31880.1};
GN ORFNames=NIES2119_27635 {ECO:0000313|EMBL:OKH31880.1};
OS Phormidium ambiguum IAM M-71.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Oscillatoriaceae; Phormidium.
OX NCBI_TaxID=454136 {ECO:0000313|EMBL:OKH31880.1, ECO:0000313|Proteomes:UP000185860};
RN [1] {ECO:0000313|EMBL:OKH31880.1, ECO:0000313|Proteomes:UP000185860}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAM M-71 {ECO:0000313|EMBL:OKH31880.1,
RC ECO:0000313|Proteomes:UP000185860};
RA Zhu T., Hou S., Lu X., Hess W.R.;
RT "Draft Genome Sequences of Nine Cyanobacterial Strains from Diverse
RT Habitats.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH31880.1}.
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DR EMBL; MRCE01000045; OKH31880.1; -; Genomic_DNA.
DR RefSeq; WP_073596710.1; NZ_MRCE01000045.1.
DR AlphaFoldDB; A0A1U7I6H2; -.
DR STRING; 454136.NIES2119_27635; -.
DR OrthoDB; 9793589at2; -.
DR Proteomes; UP000185860; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR CDD; cd01988; Na_H_Antiporter_C; 1.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.12370; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR43562:SF4; NA(+)_H(+) ANTIPORTER NHAS5; 1.
DR PANTHER; PTHR43562; NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF00582; Usp; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000185860};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..381
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 415..546
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
SQ SEQUENCE 691 AA; 75517 MW; 1B58129E7AC2C8AF CRC64;
MESILHVVQQ PIVPFAILLA VILIVPPLFE KFRLPGLVGL LAAGVILGPN ALNILQTKQP
TMELLSDIGL VYLMFVAGLE VDMEQFRKTK YRSAGFGSLT FIVPLIFGTT VGRIFNFDWN
ASILIGSLFA SHTLLAYPIV SRLGVVGNEA VTVTIGATIF TDIGALLVLA VCIAIHKGEF
SVTSLFTLLG MLIVYSAIVL FGFDWAGRQF FRRTGDDQGN QFLFVLLAVF LAALGAELIG
VEKIVGAFLA GLAVNDAIGE GPVKEKVIFV GSVLFIPAFF VDMGLLIDIP GFLKSLSSIW
LTVAIVIGLI VSKFLAALFA KLLYRYNNQE LLTMWSLSMP QVAATLAAAL VGFRAGMLSE
GVLNSVLVLM LVTATLGPLI TSKVAPGLRL PETNIVPVEE KEEVEEKEKI TSRFTVVVPV
RNPQTERFLI EIASILAKHE GGRILPLAIP QAHAHMDASE LDNALKRNQT LLKRAMEMSR
EFGVEAEPIL RIDDAIAQGI SRASRENDAN LIVMGWSNRT SFRARLFGNV IDGVLWASHC
PVAITRLLDS PSKIQRILVP VENLTNQAVR LIRFTKILAE ANQAQLTLLN VCDRRTSDNK
IAWTTSQMNL LVEKWIPNIN TDIQVIANDD IVKTVLHASQ LSDLVVLRSE RQRTAGGLAM
SNITTEIVQH LSCSFVLLGE PQKNYRGAVS Y
//
